Intercellular communication and ion channels in neuropathic pain chronicization.
Inflamm Res
; 69(9): 841-850, 2020 Sep.
Article
em En
| MEDLINE
| ID: mdl-32533221
ABSTRACT
BACKGROUND:
Neuropathic pain is caused by primary lesion or dysfunction of either peripheral or central nervous system. Due to its complex pathogenesis, often related to a number of comorbidities, such as cancer, neurodegenerative and neurovascular diseases, neuropathic pain still represents an unmet clinical need, lacking long-term effective treatment and complex case-by-case approach. AIM ANDMETHODS:
We analyzed the recent literature on the role of selective voltage-sensitive sodium, calcium and potassium permeable channels and non-selective gap junctions (GJs) and hemichannels (HCs) in establishing and maintaining chronic neuropathic conditions. We finally focussed our review on the role of extracellular microenvironment modifications induced by resident glial cells and on the recent advances in cell-to-cell and cell-to-extracellular environment communication in chronic neuropathies.CONCLUSION:
In this review, we provide an update on the current knowledge of neuropathy chronicization processes with a focus on both neuronal and glial ion channels, as well as on channel-mediated intercellular communication.Palavras-chave
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Comunicação Celular
/
Canais Iônicos
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Neuralgia
Limite:
Animals
/
Humans
Idioma:
En
Ano de publicação:
2020
Tipo de documento:
Article