Diffuse optical assessment of cerebral-autoregulation in older adults stratified by cerebrovascular risk.
J Biophotonics
; 13(10): e202000073, 2020 10.
Article
em En
| MEDLINE
| ID: mdl-32533642
ABSTRACT
Diagnosis of cerebrovascular disease (CVD) at early stages is essential for preventing sequential complications. CVD is often associated with abnormal cerebral microvasculature, which may impact cerebral-autoregulation (CA). A novel hybrid near-infrared diffuse optical instrument and a finger plethysmograph were used to simultaneously detect low-frequency oscillations (LFOs) of cerebral blood flow (CBF), oxy-hemoglobin concentration ([HbO2 ]), deoxy-hemoglobin concentration ([Hb]) and mean arterial pressure (MAP) in older adults before, during and after 70° head-up-tilting (HUT). The participants with valid data were divided based on Framingham risk score (FRS, 1-30 points) into low-risk (FRS ≤15, n = 13) and high-risk (FRS >15, n = 11) groups for developing CVD. The LFO gains were determined by transfer function analyses with MAP as the input, and CBF, [HbO2 ] and [Hb] as the outputs (CA â 1/Gain). At resting-baseline, LFO gains in the high-risk group were relatively lower compared to the low-risk group. The lower baseline gains in the high-risk group may attribute to compensatory mechanisms to maintain stronger steady-state CAs. However, HUT resulted in smaller gain reductions in the high-risk group compared to the low-risk group, suggesting weaker dynamic CAs. LFO gains are potentially valuable biomarkers for early detection of CVD based on associations with CAs.
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Base de dados:
MEDLINE
Assunto principal:
Circulação Cerebrovascular
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Espectroscopia de Luz Próxima ao Infravermelho
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Homeostase
Tipo de estudo:
Etiology_studies
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Risk_factors_studies
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Screening_studies
Limite:
Aged
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Humans
Idioma:
En
Ano de publicação:
2020
Tipo de documento:
Article