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Tumour dormancy in inflammatory microenvironment: A promising therapeutic strategy for cancer-related bone metastasis.
Hu, Wenhui; Zhang, Lincheng; Dong, Yutong; Tian, Zhansong; Chen, Yueqi; Dong, Shiwu.
Afiliação
  • Hu W; Department of Biomedical Materials Science, Third Military Medical University (Army Medical University), Chongqing, 400038, China.
  • Zhang L; Department of Biomedical Materials Science, Third Military Medical University (Army Medical University), Chongqing, 400038, China.
  • Dong Y; Department of Biomedical Materials Science, Third Military Medical University (Army Medical University), Chongqing, 400038, China.
  • Tian Z; Department of Biomedical Materials Science, Third Military Medical University (Army Medical University), Chongqing, 400038, China.
  • Chen Y; Department of Biomedical Materials Science, Third Military Medical University (Army Medical University), Chongqing, 400038, China. chenyueqi1012@sina.com.
  • Dong S; Department of Orthopedics, Southwest Hospital, Third Military Medical University (Army Medical University), Chongqing, 400038, China. chenyueqi1012@sina.com.
Cell Mol Life Sci ; 77(24): 5149-5169, 2020 Dec.
Article em En | MEDLINE | ID: mdl-32556373
Cancer metastasis is a unique feature of malignant tumours. Even bone can become a common colonization site due to the tendency of solid tumours, including breast cancer (BCa) and prostate cancer (PCa), to metastasize to bone. Currently, a previous concept in tumour metabolism called tumour dormancy may be a promising target for antitumour treatment. When disseminated tumour cells (DTCs) metastasize to the bone microenvironment, they form a flexible regulatory network called the "bone-tumour-inflammation network". In this network, bone turnover as well as metabolism, tumour progression, angiogenesis and inflammatory responses are highly unified and coordinated, and a slight shift in this balance can result in the disruption of the microenvironment, uncontrolled inflammatory responses and excessive tumour growth. The purpose of this review is to highlight the regulatory effect of the "bone-tumour-inflammation network" in tumour dormancy. Osteoblast-secreted factors, bone turnover and macrophages are emphasized and occupy in the main part of the review. In addition, the prospective clinical application of tumour dormancy is also discussed, which shows the direction of future research.
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Neoplasias da Próstata / Neoplasias Ósseas / Neoplasias da Mama / Inflamação Limite: Female / Humans / Male Idioma: En Ano de publicação: 2020 Tipo de documento: Article

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Neoplasias da Próstata / Neoplasias Ósseas / Neoplasias da Mama / Inflamação Limite: Female / Humans / Male Idioma: En Ano de publicação: 2020 Tipo de documento: Article