Extracts and Steroids from the Edible Mushroom Hypholoma lateritium Exhibit Anti-Inflammatory Properties by Inhibition of COX-2 and Activation of Nrf2.
Chem Biodivers
; 17(9): e2000391, 2020 Sep.
Article
em En
| MEDLINE
| ID: mdl-32558141
ABSTRACT
Hypholoma lateritium is an edible macrofungus with a common distribution in Europe, North America, and the Far East. The aim of this study was to investigate the potential anti-inflammatory effects of H. lateritium extracts and its isolated steroids fasciculic acid B, fasciculol E, fasciculol C, lanosta-7,9(11)-diene-12ß,21α-epoxy-2α,3ß,24ß,25-tetraol, fasciculol F, and demethylincisterol A2. Organic (hexane, chloroform and 50 % methanol) and water extracts of H. lateritium were subjected to inâ
vitro assays to determine pro-inflammatory protein levels, such as cyclooxygenase-2 (COX-2), cytosolic prostaglandin E2 synthase (cPGES), and antioxidant nuclear factor (erythroid-derived 2)-like 2 (Nrf2). Fungal extracts demonstrated significant activities on pro-inflammatory protein levels with minor differences among the activities of the fractions of different polarities. All the compounds proved to exert notable inhibitory properties on COX-2 and were capable to stimulate the Nrf2 pathway. Fungal extracts and the compounds exerted no cytotoxic activities on RAW 264.7 cells.
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Base de dados:
MEDLINE
Assunto principal:
Esteroides
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Agaricales
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Ciclo-Oxigenase 2
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Fator 2 Relacionado a NF-E2
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Inibidores de Ciclo-Oxigenase 2
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Anti-Inflamatórios
Limite:
Animals
Idioma:
En
Ano de publicação:
2020
Tipo de documento:
Article