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γ-aminobutyric acid stimulates ß-cell proliferation through the mTORC1/p70S6K pathway, an effect amplified by Ly49, a novel γ-aminobutyric acid type A receptor positive allosteric modulator.
Untereiner, Ashley; Xu, Jie; Bhattacharjee, Alpana; Cabrera, Over; Hu, Cheng; Dai, Feihan F; Wheeler, Michael B.
Afiliação
  • Untereiner A; Department of Physiology, University of Toronto, Toronto, Ontario, Canada.
  • Xu J; Department of Physiology, University of Toronto, Toronto, Ontario, Canada.
  • Bhattacharjee A; Shanghai Diabetes Institute, Shanghai Key Laboratory of Diabetes Mellitus, Shanghai Key Clinical Center for Metabolic Diseases, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, Shanghai, China.
  • Cabrera O; Toronto General Hospital Research Institute, University Health Network, Toronto, Ontario, Canada.
  • Hu C; Diabetes and Complications Research, Eli Lilly and Company, Lilly Corporate Center, Indianapolis, Indiana, USA.
  • Dai FF; Shanghai Diabetes Institute, Shanghai Key Laboratory of Diabetes Mellitus, Shanghai Key Clinical Center for Metabolic Diseases, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, Shanghai, China.
  • Wheeler MB; Institute for Metabolic Disease, Fengxian Central Hospital Affiliated to Southern Medical University, Shanghai, China.
Diabetes Obes Metab ; 22(11): 2021-2031, 2020 11.
Article em En | MEDLINE | ID: mdl-32558194
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Receptores de GABA / Proteínas Quinases S6 Ribossômicas 70-kDa Limite: Animals Idioma: En Ano de publicação: 2020 Tipo de documento: Article
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Receptores de GABA / Proteínas Quinases S6 Ribossômicas 70-kDa Limite: Animals Idioma: En Ano de publicação: 2020 Tipo de documento: Article