Connexin 43 prevents the progression of diabetic renal tubulointerstitial fibrosis by regulating the SIRT1-HIF-1&#945; signaling pathway.

Sun, Xiaohong; Huang, Kaipeng; Haiming, Xiao; Lin, Zeyuan; Yang, Yan; Zhang, Meng; Liu, Peiqing; Huang, Heqing

Connexin 43 prevents the progression of diabetic renal tubulointerstitial fibrosis by regulating the SIRT1-HIF-1α signaling pathway.

Sun, Xiaohong; Huang, Kaipeng; Haiming, Xiao; Lin, Zeyuan; Yang, Yan; Zhang, Meng; Liu, Peiqing; Huang, Heqing.

Afiliação

Sun X; Laboratory of Pharmacology and Toxicology, School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou 510006, China.
Huang K; Phase I Clinical Trial Center, Guangzhou Eighth People's Hospital, Guangzhou Medical University, Guangzhou 510060, China.
Haiming X; Laboratory of Pharmacology and Toxicology, School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou 510006, China.
Lin Z; Laboratory of Pharmacology and Toxicology, School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou 510006, China.
Yang Y; Laboratory of Pharmacology and Toxicology, School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou 510006, China.
Zhang M; Laboratory of Pharmacology and Toxicology, School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou 510006, China.
Liu P; Laboratory of Pharmacology and Toxicology, School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou 510006, China.
Huang H; Laboratory of Pharmacology and Toxicology, School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou 510006, China.

Clin Sci (Lond) ; 134(13): 1573-1592, 2020 07 17.

Article em En | MEDLINE | ID: mdl-32558900

Assuntos

Conexina 43/metabolismo; Nefropatias Diabéticas/metabolismo; Subunidade alfa do Fator 1 Induzível por Hipóxia/metabolismo; Túbulos Renais/metabolismo; Sirtuína 1/metabolismo; Animais; Conexina 43/genética; Nefropatias Diabéticas/genética; Nefropatias Diabéticas/patologia; Progressão da Doença; Fibrose/genética; Fibrose/metabolismo; Fibrose/patologia; Humanos; Subunidade alfa do Fator 1 Induzível por Hipóxia/genética; Túbulos Renais/patologia; Masculino; Camundongos; Camundongos Endogâmicos C57BL; Transdução de Sinais; Sirtuína 1/genética

Palavras-chave

Cx43; DN; EMT; HIF-1α; RIF; SIRT1

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Conexina 43 / Nefropatias Diabéticas / Subunidade alfa do Fator 1 Induzível por Hipóxia / Sirtuína 1 / Túbulos Renais Tipo de estudo: Prognostic_studies Limite: Animals / Humans / Male Idioma: En Ano de publicação: 2020 Tipo de documento: Article

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