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Predicting and elucidating the etiology of fatty liver disease: A machine learning modeling and validation study in the IMI DIRECT cohorts.
Atabaki-Pasdar, Naeimeh; Ohlsson, Mattias; Viñuela, Ana; Frau, Francesca; Pomares-Millan, Hugo; Haid, Mark; Jones, Angus G; Thomas, E Louise; Koivula, Robert W; Kurbasic, Azra; Mutie, Pascal M; Fitipaldi, Hugo; Fernandez, Juan; Dawed, Adem Y; Giordano, Giuseppe N; Forgie, Ian M; McDonald, Timothy J; Rutters, Femke; Cederberg, Henna; Chabanova, Elizaveta; Dale, Matilda; Masi, Federico De; Thomas, Cecilia Engel; Allin, Kristine H; Hansen, Tue H; Heggie, Alison; Hong, Mun-Gwan; Elders, Petra J M; Kennedy, Gwen; Kokkola, Tarja; Pedersen, Helle Krogh; Mahajan, Anubha; McEvoy, Donna; Pattou, Francois; Raverdy, Violeta; Häussler, Ragna S; Sharma, Sapna; Thomsen, Henrik S; Vangipurapu, Jagadish; Vestergaard, Henrik; 't Hart, Leen M; Adamski, Jerzy; Musholt, Petra B; Brage, Soren; Brunak, Søren; Dermitzakis, Emmanouil; Frost, Gary; Hansen, Torben; Laakso, Markku; Pedersen, Oluf.
Afiliação
  • Atabaki-Pasdar N; Genetic and Molecular Epidemiology Unit, Department of Clinical Sciences, Lund University, Malmö, Sweden.
  • Ohlsson M; Computational Biology and Biological Physics Unit, Department of Astronomy and Theoretical Physics, Lund University, Lund, Sweden.
  • Viñuela A; Center for Applied Intelligent Systems Research, Halmstad University, Halmstad, Sweden.
  • Frau F; Department of Genetic Medicine and Development, University of Geneva Medical School, Geneva, Switzerland.
  • Pomares-Millan H; Institute for Genetics and Genomics in Geneva, University of Geneva Medical School, Geneva, Switzerland.
  • Haid M; Swiss Institute of Bioinformatics, Geneva, Switzerland.
  • Jones AG; Sanofi-Aventis Deutschland, Frankfurt am Main, Germany.
  • Thomas EL; Genetic and Molecular Epidemiology Unit, Department of Clinical Sciences, Lund University, Malmö, Sweden.
  • Koivula RW; Research Unit Molecular Endocrinology and Metabolism, Helmholtz Zentrum München, Neuherberg, Germany.
  • Kurbasic A; Institute of Biomedical and Clinical Science, College of Medicine and Health, University of Exeter, Exeter, United Kingdom.
  • Mutie PM; Research Centre for Optimal Health, School of Life Sciences, University of Westminster, London, United Kingdom.
  • Fitipaldi H; Genetic and Molecular Epidemiology Unit, Department of Clinical Sciences, Lund University, Malmö, Sweden.
  • Fernandez J; Oxford Centre for Diabetes, Endocrinology and Metabolism, Radcliffe Department of Medicine, University of Oxford, Oxford, United Kingdom.
  • Dawed AY; Genetic and Molecular Epidemiology Unit, Department of Clinical Sciences, Lund University, Malmö, Sweden.
  • Giordano GN; Genetic and Molecular Epidemiology Unit, Department of Clinical Sciences, Lund University, Malmö, Sweden.
  • Forgie IM; Genetic and Molecular Epidemiology Unit, Department of Clinical Sciences, Lund University, Malmö, Sweden.
  • McDonald TJ; Genetic and Molecular Epidemiology Unit, Department of Clinical Sciences, Lund University, Malmö, Sweden.
  • Rutters F; Division of Population Health and Genomics, School of Medicine, University of Dundee, Ninewells Hospital, Dundee, United Kingdom.
  • Cederberg H; Genetic and Molecular Epidemiology Unit, Department of Clinical Sciences, Lund University, Malmö, Sweden.
  • Chabanova E; Division of Population Health and Genomics, School of Medicine, University of Dundee, Ninewells Hospital, Dundee, United Kingdom.
  • Dale M; Institute of Biomedical and Clinical Science, College of Medicine and Health, University of Exeter, Exeter, United Kingdom.
  • Masi F; Blood Sciences, Royal Devon and Exeter NHS Foundation Trust, Exeter, United Kingdom.
  • Thomas CE; Department of Epidemiology and Biostatistics, Amsterdam Public Health Research Institute, Amsterdam UMC, Amsterdam, the Netherlands.
  • Allin KH; Department of Endocrinology, Abdominal Centre, Helsinki University Hospital, Helsinki, Finland.
  • Hansen TH; Department of Diagnostic Radiology, Copenhagen University Hospital Herlev Gentofte, Herlev, Denmark.
  • Heggie A; Affinity Proteomics, Science for Life Laboratory, School of Engineering Sciences in Chemistry, Biotechnology and Health, KTH Royal Institute of Technology, Solna, Sweden.
  • Hong MG; Department of Health Technology, Technical University of Denmark, Kongens Lyngby, Denmark.
  • Elders PJM; Affinity Proteomics, Science for Life Laboratory, School of Engineering Sciences in Chemistry, Biotechnology and Health, KTH Royal Institute of Technology, Solna, Sweden.
  • Kennedy G; Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.
  • Kokkola T; Center for Clinical Research and Prevention, Bispebjerg and Frederiksberg Hospital, Copenhagen, Denmark.
  • Pedersen HK; Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.
  • Mahajan A; Department of Cardiology and Endocrinology, Slagelse Hospital, Slagelse, Denmark.
  • McEvoy D; Institute of Cellular Medicine, Newcastle University, Newcastle upon Tyne, United Kingdom.
  • Pattou F; Affinity Proteomics, Science for Life Laboratory, School of Engineering Sciences in Chemistry, Biotechnology and Health, KTH Royal Institute of Technology, Solna, Sweden.
  • Raverdy V; Department of General Practice, Amsterdam Public Health Research Institute, Amsterdam UMC, Amsterdam, the Netherlands.
  • Häussler RS; Immunoassay Biomarker Core Laboratory, School of Medicine, University of Dundee, Ninewells Hospital, Dundee, United Kingdom.
  • Sharma S; Internal Medicine, Institute of Clinical Medicine, University of Eastern Finland, Kuopio, Finland.
  • Thomsen HS; Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.
  • Vangipurapu J; Wellcome Centre for Human Genetics, University of Oxford, Oxford, United Kingdom.
  • Vestergaard H; Institute of Cellular Medicine, Newcastle University, Newcastle upon Tyne, United Kingdom.
  • 't Hart LM; University of Lille, Inserm, UMR 1190, Translational Research in Diabetes, Department of Endocrine Surgery, CHU Lille, Lille, France.
  • Adamski J; University of Lille, Inserm, UMR 1190, Translational Research in Diabetes, Department of Endocrine Surgery, CHU Lille, Lille, France.
  • Musholt PB; Affinity Proteomics, Science for Life Laboratory, School of Engineering Sciences in Chemistry, Biotechnology and Health, KTH Royal Institute of Technology, Solna, Sweden.
  • Brage S; German Center for Diabetes Research, Neuherberg, Germany.
  • Brunak S; Unit of Molecular Epidemiology, Institute of Epidemiology II, Helmholtz Zentrum München, Neuherberg, Germany.
  • Dermitzakis E; Department of Diagnostic Radiology, Copenhagen University Hospital Herlev Gentofte, Herlev, Denmark.
  • Frost G; Internal Medicine, Institute of Clinical Medicine, University of Eastern Finland, Kuopio, Finland.
  • Hansen T; Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.
  • Laakso M; Steno Diabetes Center Copenhagen, Gentofte, Denmark.
  • Pedersen O; Department of Epidemiology and Biostatistics, Amsterdam Public Health Research Institute, Amsterdam UMC, Amsterdam, the Netherlands.
PLoS Med ; 17(6): e1003149, 2020 06.
Article em En | MEDLINE | ID: mdl-32559194

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Fígado Gorduroso / Aprendizado de Máquina Tipo de estudo: Clinical_trials / Etiology_studies / Observational_studies / Prognostic_studies / Risk_factors_studies / Screening_studies Limite: Female / Humans / Male / Middle aged Idioma: En Ano de publicação: 2020 Tipo de documento: Article

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Fígado Gorduroso / Aprendizado de Máquina Tipo de estudo: Clinical_trials / Etiology_studies / Observational_studies / Prognostic_studies / Risk_factors_studies / Screening_studies Limite: Female / Humans / Male / Middle aged Idioma: En Ano de publicação: 2020 Tipo de documento: Article