1-(1-Arylethylpiperidin-4-yl)thymine Analogs as Antimycobacterial TMPK Inhibitors.

Jian, Yanlin; Hulpia, Fabian; D P Risseeuw, Martijn; Forbes, He Eun; Caljon, Guy; Munier-Lehmann, Hélène; I M Boshoff, Helena; Van Calenbergh, Serge

Jian, Yanlin; Hulpia, Fabian; D P Risseeuw, Martijn; Forbes, He Eun; Caljon, Guy; Munier-Lehmann, Hélène; I M Boshoff, Helena; Van Calenbergh, Serge.

Afiliação

Jian Y; Laboratory for Medicinal Chemistry (FFW), Ghent University, Ottergemsesteenweg 460, B-9000 Gent, Belgium.
Hulpia F; Laboratory for Medicinal Chemistry (FFW), Ghent University, Ottergemsesteenweg 460, B-9000 Gent, Belgium.
D P Risseeuw M; Laboratory for Medicinal Chemistry (FFW), Ghent University, Ottergemsesteenweg 460, B-9000 Gent, Belgium.
Forbes HE; Tuberculosis Research Section, Laboratory of Clinical Immunology and Microbiology, National Institute of Allergy and Infectious Disease, National Institutes of Health, 9000 Rockville Pike, Bethesda, MD 20892, USA.
Caljon G; Laboratory of Microbiology, Parasitology and Hygiene, University of Antwerp, Universiteitsplein 1 (S7), B-2610 Wilrijk, Belgium.
Munier-Lehmann H; Unit of Chemistry and Biocatalysis, Department of Structural Biology and Chemistry, Institut Pasteur, CNRS UMR3523, 28 Rue du Dr. Roux, CEDEX 15 75724 Paris, France.
I M Boshoff H; Tuberculosis Research Section, Laboratory of Clinical Immunology and Microbiology, National Institute of Allergy and Infectious Disease, National Institutes of Health, 9000 Rockville Pike, Bethesda, MD 20892, USA.
Van Calenbergh S; Laboratory for Medicinal Chemistry (FFW), Ghent University, Ottergemsesteenweg 460, B-9000 Gent, Belgium.

Molecules ; 25(12)2020 Jun 17.

Article em En | MEDLINE | ID: mdl-32560578

Assuntos

Antituberculosos; Proteínas de Bactérias/antagonistas & inibidores; Inibidores Enzimáticos; Mycobacterium tuberculosis/enzimologia; Núcleosídeo-Fosfato Quinase/antagonistas & inibidores; Timina; Antituberculosos/síntese química; Antituberculosos/química; Antituberculosos/farmacologia; Proteínas de Bactérias/metabolismo; Inibidores Enzimáticos/síntese química; Inibidores Enzimáticos/química; Inibidores Enzimáticos/farmacologia; Humanos; Modelos Moleculares; Estrutura Molecular; Núcleosídeo-Fosfato Quinase/metabolismo; Relação Estrutura-Atividade; Timina/análogos & derivados; Timina/síntese química; Timina/química; Timina/farmacologia

Palavras-chave

1-(1-arylethylpiperidin-4-yl)thymine; MtbTMPK; Mycobacterium tuberculosis; tuberculosis

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Timina / Proteínas de Bactérias / Núcleosídeo-Fosfato Quinase / Inibidores Enzimáticos / Mycobacterium tuberculosis / Antituberculosos Limite: Humans Idioma: En Ano de publicação: 2020 Tipo de documento: Article

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