Proposome for transdermal delivery of tofacitinib.
Int J Pharm
; 585: 119558, 2020 Jul 30.
Article
em En
| MEDLINE
| ID: mdl-32565283
ABSTRACT
Tofacitinib citrate (TC) has recently gained interest in treating skin disorders such as psoriasis, atopic dermatitis and baldness. Unfortunately, the oral administration shows side effects, such as decreased neutrophil counts. To this end, the topical delivery of TC can be used to reduce the risk associated with systemic exposure. However, TC shows minimal absorption via skin. Hence, the objective of this study is to enhance the skin delivery of TC using a non-invasive approach. The liposomes based on propylene glycol, named as proposomes, carrying TC, were studied. The vesicle characteristics and in vitro skin permeation were assessed. The proposomes enhanced the skin permeability of TC by 4-11 folds. The composition of proposomes was found to affect the skin permeation and deposition of TC. The proposomes were stable for at least 6 months. Overall, proposomes were effective for targeted topical drug delivery.
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Texto completo:
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Base de dados:
MEDLINE
Assunto principal:
Piperidinas
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Pirimidinas
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Absorção Cutânea
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Sistemas de Liberação de Medicamentos
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Inibidores de Proteínas Quinases
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Lipossomos
Limite:
Humans
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Male
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Middle aged
Idioma:
En
Ano de publicação:
2020
Tipo de documento:
Article