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Phase I Trial of First-in-Class ATR Inhibitor M6620 (VX-970) as Monotherapy or in Combination With Carboplatin in Patients With Advanced Solid Tumors.
Yap, Timothy A; O'Carrigan, Brent; Penney, Marina S; Lim, Joline S; Brown, Jessica S; de Miguel Luken, Maria J; Tunariu, Nina; Perez-Lopez, Raquel; Rodrigues, Daniel Nava; Riisnaes, Ruth; Figueiredo, Ines; Carreira, Suzanne; Hare, Brian; McDermott, Katherine; Khalique, Saira; Williamson, Chris T; Natrajan, Rachael; Pettitt, Stephen J; Lord, Christopher J; Banerji, Udai; Pollard, John; Lopez, Juanita; de Bono, Johann S.
Afiliação
  • Yap TA; Drug Development Unit, Royal Marsden Hospital, London, United Kingdom.
  • O'Carrigan B; The Institute of Cancer Research, London, United Kingdom.
  • Penney MS; Drug Development Unit, Royal Marsden Hospital, London, United Kingdom.
  • Lim JS; Vertex Pharmaceuticals, Boston, MA.
  • Brown JS; Drug Development Unit, Royal Marsden Hospital, London, United Kingdom.
  • de Miguel Luken MJ; Drug Development Unit, Royal Marsden Hospital, London, United Kingdom.
  • Tunariu N; Drug Development Unit, Royal Marsden Hospital, London, United Kingdom.
  • Perez-Lopez R; Drug Development Unit, Royal Marsden Hospital, London, United Kingdom.
  • Rodrigues DN; Drug Development Unit, Royal Marsden Hospital, London, United Kingdom.
  • Riisnaes R; The Institute of Cancer Research, London, United Kingdom.
  • Figueiredo I; The Institute of Cancer Research, London, United Kingdom.
  • Carreira S; The Institute of Cancer Research, London, United Kingdom.
  • Hare B; The Institute of Cancer Research, London, United Kingdom.
  • McDermott K; Vertex Pharmaceuticals, Boston, MA.
  • Khalique S; Vertex Pharmaceuticals, Boston, MA.
  • Williamson CT; Breast Cancer Now Toby Robins Research Centre, The Institute of Cancer Research, London, United Kingdom.
  • Natrajan R; Breast Cancer Now Toby Robins Research Centre, The Institute of Cancer Research, London, United Kingdom.
  • Pettitt SJ; CRUK Gene Function Laboratory, The Institute of Cancer Research, London, United Kingdom.
  • Lord CJ; Breast Cancer Now Toby Robins Research Centre, The Institute of Cancer Research, London, United Kingdom.
  • Banerji U; Breast Cancer Now Toby Robins Research Centre, The Institute of Cancer Research, London, United Kingdom.
  • Pollard J; CRUK Gene Function Laboratory, The Institute of Cancer Research, London, United Kingdom.
  • Lopez J; Breast Cancer Now Toby Robins Research Centre, The Institute of Cancer Research, London, United Kingdom.
  • de Bono JS; CRUK Gene Function Laboratory, The Institute of Cancer Research, London, United Kingdom.
J Clin Oncol ; 38(27): 3195-3204, 2020 09 20.
Article em En | MEDLINE | ID: mdl-32568634
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Pirazinas / Protocolos de Quimioterapia Combinada Antineoplásica / Isoxazóis / Neoplasias / Antineoplásicos Limite: Aged / Female / Humans / Male / Middle aged Idioma: En Ano de publicação: 2020 Tipo de documento: Article
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Pirazinas / Protocolos de Quimioterapia Combinada Antineoplásica / Isoxazóis / Neoplasias / Antineoplásicos Limite: Aged / Female / Humans / Male / Middle aged Idioma: En Ano de publicação: 2020 Tipo de documento: Article