Double the Fun, Double the Trouble: Paralogs and Homologs Functioning in the Endoplasmic Reticulum.
Annu Rev Biochem
; 89: 637-666, 2020 06 20.
Article
em En
| MEDLINE
| ID: mdl-32569522
ABSTRACT
The evolution of eukaryotic genomes has been propelled by a series of gene duplication events, leading to an expansion in new functions and pathways. While duplicate genes may retain some functional redundancy, it is clear that to survive selection they cannot simply serve as a backup but rather must acquire distinct functions required for cellular processes to work accurately and efficiently. Understanding these differences and characterizing gene-specific functions is complex. Here we explore different gene pairs and families within the context of the endoplasmic reticulum (ER), the main cellular hub of lipid biosynthesis and the entry site for the secretory pathway. Focusing on each of the ER functions, we highlight specificities of related proteins and the capabilities conferred to cells through their conservation. More generally, these examples suggest why related genes have been maintained by evolutionary forces and provide a conceptual framework to experimentally determine why they have survived selection.
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MEDLINE
Assunto principal:
Saccharomyces cerevisiae
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Seleção Genética
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Evolução Molecular
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Duplicação Gênica
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Retículo Endoplasmático
Limite:
Animals
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Humans
Idioma:
En
Ano de publicação:
2020
Tipo de documento:
Article