Hepatitis B virus mutation pattern rtA181S+T184I+M204I may contribute to multidrug resistance in clinical practice: Analysis of a large cohort of Chinese patients.

Chen, Rongjuan; Liu, Yan; Luo, Dan; Si, Lanlan; Huang, Bixia; Wang, Jun; Li, Xiaodong; Cheng, Fengjuan; Xu, Dongping; Duan, Changzhu

Chen, Rongjuan; Liu, Yan; Luo, Dan; Si, Lanlan; Huang, Bixia; Wang, Jun; Li, Xiaodong; Cheng, Fengjuan; Xu, Dongping; Duan, Changzhu.

Afiliação

Chen R; Department of Cell Biology and Genetics, Molecular Medicine and Cancer Research Center, Chongqing Medical University, Chongqing, 400016, China; Institute of Infectious Diseases, The Fifth Medical Center of Chinese PLA General Hospital, Beijing, 100039, China.
Liu Y; Institute of Infectious Diseases, The Fifth Medical Center of Chinese PLA General Hospital, Beijing, 100039, China.
Luo D; Institute of Infectious Diseases, The Fifth Medical Center of Chinese PLA General Hospital, Beijing, 100039, China.
Si L; Institute of Infectious Diseases, The Fifth Medical Center of Chinese PLA General Hospital, Beijing, 100039, China.
Huang B; Institute of Infectious Diseases, The Fifth Medical Center of Chinese PLA General Hospital, Beijing, 100039, China.
Wang J; Institute of Infectious Diseases, The Fifth Medical Center of Chinese PLA General Hospital, Beijing, 100039, China.
Li X; Institute of Infectious Diseases, The Fifth Medical Center of Chinese PLA General Hospital, Beijing, 100039, China.
Cheng F; Department of Cell Biology and Genetics, Molecular Medicine and Cancer Research Center, Chongqing Medical University, Chongqing, 400016, China.
Xu D; Institute of Infectious Diseases, The Fifth Medical Center of Chinese PLA General Hospital, Beijing, 100039, China. Electronic address: xudongping302@sina.com.
Duan C; Department of Cell Biology and Genetics, Molecular Medicine and Cancer Research Center, Chongqing Medical University, Chongqing, 400016, China. Electronic address: duanchzhu@cqmu.edu.cn.

Antiviral Res ; 180: 104852, 2020 08.

Article em En | MEDLINE | ID: mdl-32569703

Assuntos

Antivirais/farmacologia; Farmacorresistência Viral Múltipla/genética; Vírus da Hepatite B/efeitos dos fármacos; Vírus da Hepatite B/genética; Hepatite B Crônica/epidemiologia; Adenina/análogos & derivados; Adenina/uso terapêutico; Adulto; Antivirais/uso terapêutico; Povo Asiático; Pequim/epidemiologia; Estudos de Coortes; DNA Viral/genética; Feminino; Guanina/análogos & derivados; Guanina/uso terapêutico; Hepatite B Crônica/tratamento farmacológico; Hepatite B Crônica/virologia; Humanos; Estudos Longitudinais; Masculino; Pessoa de Meia-Idade; Mutação; Organofosfonatos/uso terapêutico; Prevalência

Palavras-chave

Adefovir; Entecavir; Hepatitis B virus; Multidrug-resistance; Mutation; rtA181S+T184I+M204I

Texto completo

Imprimir

XML

PubMed Links

Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Antivirais / Vírus da Hepatite B / Hepatite B Crônica / Farmacorresistência Viral Múltipla Tipo de estudo: Etiology_studies / Incidence_studies / Observational_studies / Prevalence_studies / Risk_factors_studies Limite: Adult / Female / Humans / Male / Middle aged País como assunto: Asia Idioma: En Ano de publicação: 2020 Tipo de documento: Article

Texto completo

Imprimir

XML

PubMed Links

Buscar no Google