Renal Impairment Increases Serum Cancer Antigen 125 Levels in Patients with Type 2 Diabetes Mellitus.

ABSTRACT

OBJECTIVE: Poor glycemic control increases the risk of diabetes complications. Serum cancer antigen 125 (CA125) has been associated with diabetes status in patients with type 2 diabetes mellitus (T2DM). Our aim was to focus on the association between serum CA125 and renal impairment in patients with T2DM. METHODS: Retrospective study included 151 patients with T2DM, with review of clinical and laboratory data. RESULTS: Serum CA125 levels were positively correlated with urinary microalbumin and 24-hours urinary protein (r=0.170, p=0.037; r=0.186, p=0.022) in T2DM patients. Patients with 24-hours urinary protein positive maintained higher serum CA125 levels than those with 24-hours urinary protein negative (p=0.047). Multiple linear regression analysis indicated that serum CA125 was independently correlated with urinary microalbumin and 24-hours urinary protein in T2DM patients (beta=0.192, p=0.042; beta=0.203, p=0.025). CONCLUSIONS: Serum CA125 levels are positively correlated with urinary microalbumin and 24-hours urinary protein in T2DM patients; renal impairment may increase serum CA125 levels in T2DM patients.