Nicotinic acid adenine dinucleotide phosphate activates two-pore channel TPC1 to mediate lysosomal Ca<sup>2+</sup> release in endothelial colony-forming cells.

Moccia, Francesco; Zuccolo, Estella; Di Nezza, Francesca; Pellavio, Giorgia; Faris, Pawan S; Negri, Sharon; De Luca, Antonio; Laforenza, Umberto; Ambrosone, Luigi; Rosti, Vittorio; Guerra, Germano

Nicotinic acid adenine dinucleotide phosphate activates two-pore channel TPC1 to mediate lysosomal Ca²⁺ release in endothelial colony-forming cells.

Moccia, Francesco; Zuccolo, Estella; Di Nezza, Francesca; Pellavio, Giorgia; Faris, Pawan S; Negri, Sharon; De Luca, Antonio; Laforenza, Umberto; Ambrosone, Luigi; Rosti, Vittorio; Guerra, Germano.

Afiliação

Moccia F; Department of Biology and Biotechnology, Laboratory of General Physiology, University of Pavia, Pavia, Italy.
Zuccolo E; Department of Biology and Biotechnology, Laboratory of General Physiology, University of Pavia, Pavia, Italy.
Di Nezza F; Department of Medicine and Health Sciences "Vincenzo Tiberio", University of Molise, Campobasso, Italy.
Pellavio G; Human Physiology Unit, Department of Molecular Medicine, University of Pavia, Pavia, Italy.
Faris PS; Department of Biology and Biotechnology, Laboratory of General Physiology, University of Pavia, Pavia, Italy.
Negri S; Department of Biology and Biotechnology, Laboratory of General Physiology, University of Pavia, Pavia, Italy.
De Luca A; Department of Mental and Physical Health and Preventive Medicine, University of Campania Luigi Vanvitelli, Naples, Italy.
Laforenza U; Human Physiology Unit, Department of Molecular Medicine, University of Pavia, Pavia, Italy.
Ambrosone L; Department of Medicine and Health Sciences "Vincenzo Tiberio", University of Molise, Campobasso, Italy.
Rosti V; Laboratory of Biochemistry Biotechnology and Advanced Diagnostic, Myelofibrosis Study Centre, IRCCS Ospedale Policlinico San Matteo, Pavia, Italy.
Guerra G; Department of Medicine and Health Sciences "Vincenzo Tiberio", University of Molise, Campobasso, Italy.

J Cell Physiol ; 236(1): 688-705, 2021 01.

Article em En | MEDLINE | ID: mdl-32583526

Assuntos

Canais de Cálcio/efeitos dos fármacos; Retículo Endoplasmático/efeitos dos fármacos; Células Endoteliais/efeitos dos fármacos; NADP/análogos & derivados; Cálcio/metabolismo; Canais de Cálcio/metabolismo; Sinalização do Cálcio/efeitos dos fármacos; Sinalização do Cálcio/fisiologia; Linhagem Celular; Retículo Endoplasmático/metabolismo; Células Endoteliais/metabolismo; Humanos; Lisossomos/efeitos dos fármacos; Lisossomos/metabolismo; NADP/metabolismo; NADP/farmacologia; Fator A de Crescimento do Endotélio Vascular/efeitos dos fármacos; Fator A de Crescimento do Endotélio Vascular/metabolismo

Palavras-chave

Ca2+ signaling; NAADP; VEGF; endothelial colony-forming cells; two-pore channel 1

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Canais de Cálcio / Células Endoteliais / Retículo Endoplasmático / NADP Limite: Humans Idioma: En Ano de publicação: 2021 Tipo de documento: Article

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