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Variation in RARG increases susceptibility to doxorubicin-induced cardiotoxicity in patient specific induced pluripotent stem cell-derived cardiomyocytes.
Christidi, Effimia; Huang, Haojun; Shafaattalab, Sanam; Maillet, Agnes; Lin, Eric; Huang, Kate; Laksman, Zachary; Davis, Margot K; Tibbits, Glen F; Brunham, Liam R.
Afiliação
  • Christidi E; Centre for Heart Lung Innovation, Department of Medicine, University of British Columbia, Vancouver, Canada.
  • Huang H; Centre for Heart Lung Innovation, Department of Medicine, University of British Columbia, Vancouver, Canada.
  • Shafaattalab S; Molecular Cardiac Physiology Group, Department of Biomedical Physiology and Kinesiology, Simon Fraser University, Burnaby, Canada.
  • Maillet A; Department of Cardiovascular Science, British Columbia Children's Hospital, Vancouver, Canada.
  • Lin E; Astellas Pharma Europe B.V., Leiden, Netherlands.
  • Huang K; Molecular Cardiac Physiology Group, Department of Biomedical Physiology and Kinesiology, Simon Fraser University, Burnaby, Canada.
  • Laksman Z; Centre for Heart Lung Innovation, Department of Medicine, University of British Columbia, Vancouver, Canada.
  • Davis MK; Heart Rhythm Services, Division of Cardiology, Department of Medicine, University of British Columbia, Vancouver, Canada.
  • Tibbits GF; Department of Medicine, University of British Columbia, Vancouver, British Columbia, Canada.
  • Brunham LR; Department of Medicine, University of British Columbia, Vancouver, British Columbia, Canada.
Sci Rep ; 10(1): 10363, 2020 06 25.
Article em En | MEDLINE | ID: mdl-32587261
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Doxorrubicina / Receptores do Ácido Retinoico / Miócitos Cardíacos / Células-Tronco Pluripotentes Induzidas / Cardiotoxicidade / Mutação / Neoplasias Tipo de estudo: Etiology_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Limite: Adult / Aged / Aged80 / Female / Humans / Male / Middle aged Idioma: En Ano de publicação: 2020 Tipo de documento: Article
Texto completo
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XML
PubMed Links
Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Doxorrubicina / Receptores do Ácido Retinoico / Miócitos Cardíacos / Células-Tronco Pluripotentes Induzidas / Cardiotoxicidade / Mutação / Neoplasias Tipo de estudo: Etiology_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Limite: Adult / Aged / Aged80 / Female / Humans / Male / Middle aged Idioma: En Ano de publicação: 2020 Tipo de documento: Article