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The inhibitory complex of human alpha 1-proteinase inhibitor and human leukocyte elastase is a neutrophil chemoattractant.
Banda, M J; Rice, A G; Griffin, G L; Senior, R M.
Afiliação
  • Banda MJ; Laboratory of Radiobiology and Environmental Health, University of California, San Francisco 94143.
J Exp Med ; 167(5): 1608-15, 1988 May 01.
Article em En | MEDLINE | ID: mdl-3259253
An inhibitor-proteinase complex consisting of human alpha 1-PI and human leukocyte elastase is chemotactic for human neutrophils. The chemotactic activity is optimal at 1 nM and is associated only with the alpha 1-PI portion of the complex. Neither HLE in the complex, free HLE, nor native alpha 1-PI possesses chemotactic activity for human neutrophils. alpha 1-PI in complex is hydrolyzed at the Met-358-Ser-359 bond. The chemotactic activity is associated with the Mr 4,200 fragment of alpha 1-PI that has Ser-359 as its NH2 terminus. The region of the HLE-alpha 1-PI complex that stimulates chemotaxis appears to be the same as that of the Mr 4,200 fragment generated by hydrolysis of the Pro-357-Met-358 bond during proteolytic inactivation of alpha 1-PI. The data suggest the presence of a neutrophil surface receptor bound by alpha 1-PI after the formation of a complex with HLE or after proteolytic degradation. This receptor may play a role in clearance of these modified alpha 1-PI molecules.
Assuntos

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Proteínas Sanguíneas / Elastase Pancreática / Fatores Quimiotáticos / Neutrófilos Limite: Humans Idioma: En Ano de publicação: 1988 Tipo de documento: Article

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Proteínas Sanguíneas / Elastase Pancreática / Fatores Quimiotáticos / Neutrófilos Limite: Humans Idioma: En Ano de publicação: 1988 Tipo de documento: Article