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Cryo-EM structures of NPC1L1 reveal mechanisms of cholesterol transport and ezetimibe inhibition.
Huang, Ching-Shin; Yu, Xinchao; Fordstrom, Preston; Choi, Kaylee; Chung, Ben C; Roh, Soung-Hun; Chiu, Wah; Zhou, Mingyue; Min, Xiaoshan; Wang, Zhulun.
Afiliação
  • Huang CS; Department of Therapeutic Discovery, Amgen Research, Amgen Inc., 1120 Veterans Blvd., South San Francisco, CA 94080, USA.
  • Yu X; Department of Therapeutic Discovery, Amgen Research, Amgen Inc., 1120 Veterans Blvd., South San Francisco, CA 94080, USA.
  • Fordstrom P; Department of Cardiometabolic Disorders, Amgen Research, Amgen Inc., 1120 Veterans Blvd., South San Francisco, CA 94080, USA.
  • Choi K; Department of Therapeutic Discovery, Amgen Research, Amgen Inc., 1120 Veterans Blvd., South San Francisco, CA 94080, USA.
  • Chung BC; Department of Therapeutic Discovery, Amgen Research, Amgen Inc., 1120 Veterans Blvd., South San Francisco, CA 94080, USA.
  • Roh SH; Department of Bioengineering and James H. Clark Center, Stanford University, Stanford, CA 94305, USA.
  • Chiu W; Department of Bioengineering and James H. Clark Center, Stanford University, Stanford, CA 94305, USA.
  • Zhou M; Division of Cryo-EM and Bioimaging, SLAC National Accelerator Laboratory, Menlo Park, CA 94025, USA.
  • Min X; Department of Cardiometabolic Disorders, Amgen Research, Amgen Inc., 1120 Veterans Blvd., South San Francisco, CA 94080, USA.
  • Wang Z; Department of Therapeutic Discovery, Amgen Research, Amgen Inc., 1120 Veterans Blvd., South San Francisco, CA 94080, USA.
Sci Adv ; 6(25): eabb1989, 2020 06.
Article em En | MEDLINE | ID: mdl-32596471
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Texto completo: 1 Base de dados: MEDLINE Idioma: En Ano de publicação: 2020 Tipo de documento: Article
Texto completo
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PubMed Links
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Texto completo: 1 Base de dados: MEDLINE Idioma: En Ano de publicação: 2020 Tipo de documento: Article