Pharmaco-genetic inhibition of pyramidal neurons retards hippocampal kindling-induced epileptogenesis.

Chen, Li-Ying; Liang, Jiao; Fei, Fan; Ruan, Ye-Ping; Cheng, He-Ming; Wang, Yi; Chen, Zhong; Xu, Ceng-Lin

Chen, Li-Ying; Liang, Jiao; Fei, Fan; Ruan, Ye-Ping; Cheng, He-Ming; Wang, Yi; Chen, Zhong; Xu, Ceng-Lin.

Afiliação

Chen LY; Institute of Pharmacology & Toxicology, NHC and CAMS Key Laboratory of Medical Neurobiology, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou, China.
Liang J; Institute of Pharmacology & Toxicology, NHC and CAMS Key Laboratory of Medical Neurobiology, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou, China.
Fei F; Department of Neurology, Epilepsy Center, Second Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, China.
Ruan YP; Institute of Pharmacology & Toxicology, NHC and CAMS Key Laboratory of Medical Neurobiology, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou, China.
Cheng HM; College of Pharmaceutical Science, Zhejiang Chinese Medical University, Hangzhou, China.
Wang Y; Institute of Pharmacology & Toxicology, NHC and CAMS Key Laboratory of Medical Neurobiology, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou, China.
Chen Z; Institute of Pharmacology & Toxicology, NHC and CAMS Key Laboratory of Medical Neurobiology, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou, China.
Xu CL; College of Pharmaceutical Science, Zhejiang Chinese Medical University, Hangzhou, China.

CNS Neurosci Ther ; 26(11): 1111-1120, 2020 11.

Article em En | MEDLINE | ID: mdl-32596972

Assuntos

Anticonvulsivantes/administração & dosagem; Hipocampo/fisiologia; Excitação Neurológica/fisiologia; Engenharia de Proteínas/métodos; Células Piramidais/fisiologia; Convulsões/prevenção & controle; Animais; Terapia Combinada/métodos; Hipocampo/efeitos dos fármacos; Excitação Neurológica/efeitos dos fármacos; Masculino; Camundongos; Camundongos Transgênicos; Células Piramidais/efeitos dos fármacos; Receptores Muscarínicos/genética; Receptores Muscarínicos/metabolismo; Convulsões/genética; Convulsões/fisiopatologia

Palavras-chave

epilepsy; parvalbumin neurons; pharmaco-genetics; pyramidal neurons; synaptic plasticity

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Convulsões / Engenharia de Proteínas / Células Piramidais / Hipocampo / Excitação Neurológica / Anticonvulsivantes Limite: Animals Idioma: En Ano de publicação: 2020 Tipo de documento: Article

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