Association of End Point Definition and Randomized Clinical Trial Duration in Clinical Trials of Schizophrenia Medications.

Younis, Islam R; Gopalakrishnan, Mathangi; Mathis, Mitchell; Mehta, Mehul; Uppoor, Ramana; Zhu, Hao; Farchione, Tiffany

Younis, Islam R; Gopalakrishnan, Mathangi; Mathis, Mitchell; Mehta, Mehul; Uppoor, Ramana; Zhu, Hao; Farchione, Tiffany.

Afiliação

Younis IR; Office of Clinical Pharmacology, Office of Translational Sciences, Center for Drug Evaluation and Research, US Food and Drug Administration, Silver Spring, Maryland.
Gopalakrishnan M; Office of Clinical Pharmacology, Office of Translational Sciences, Center for Drug Evaluation and Research, US Food and Drug Administration, Silver Spring, Maryland.
Mathis M; Center for Translational Medicine, University of Maryland, Baltimore.
Mehta M; Division of Psychiatry Products, Office of New Drugs, Center for Drug Evaluation and Research, US Food and Drug Administration, Silver Spring, Maryland.
Uppoor R; Office of Clinical Pharmacology, Office of Translational Sciences, Center for Drug Evaluation and Research, US Food and Drug Administration, Silver Spring, Maryland.
Zhu H; Office of Clinical Pharmacology, Office of Translational Sciences, Center for Drug Evaluation and Research, US Food and Drug Administration, Silver Spring, Maryland.
Farchione T; Office of Clinical Pharmacology, Office of Translational Sciences, Center for Drug Evaluation and Research, US Food and Drug Administration, Silver Spring, Maryland.

JAMA Psychiatry ; 77(10): 1064-1071, 2020 10 01.

Article em En | MEDLINE | ID: mdl-32609294

Assuntos

Antipsicóticos/uso terapêutico; Determinação de Ponto Final; Ensaios Clínicos Controlados Aleatórios como Assunto; Esquizofrenia/tratamento farmacológico; Psicologia do Esquizofrênico; Adulto; Idoso; Antipsicóticos/efeitos adversos; Causas de Morte; Estudos de Coortes; Efeitos Psicossociais da Doença; Transtorno Depressivo/tratamento farmacológico; Transtorno Depressivo/mortalidade; Transtorno Depressivo/psicologia; Duração da Terapia; Feminino; Humanos; Masculino; Pessoa de Meia-Idade; Fatores de Risco; Esquizofrenia/mortalidade

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Esquizofrenia / Psicologia do Esquizofrênico / Antipsicóticos / Ensaios Clínicos Controlados Aleatórios como Assunto / Determinação de Ponto Final Tipo de estudo: Clinical_trials / Etiology_studies / Incidence_studies / Observational_studies / Risk_factors_studies Limite: Adult / Aged / Female / Humans / Male / Middle aged Idioma: En Ano de publicação: 2020 Tipo de documento: Article

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