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The Prospective Studies of Atherosclerosis (Proof-ATHERO) Consortium: Design and Rationale.
Tschiderer, Lena; Seekircher, Lisa; Klingenschmid, Gerhard; Izzo, Raffaele; Baldassarre, Damiano; Iglseder, Bernhard; Calabresi, Laura; Liu, Jing; Price, Jackie F; Bae, Jang-Ho; Brouwers, Frank P; de Groot, Eric; Schmidt, Caroline; Bergström, Göran; Asçi, Gülay; Gresele, Paolo; Okazaki, Shuhei; Kapellas, Kostas; Landecho, Manuel F; Sattar, Naveed; Agewall, Stefan; Zou, Zhi-Yong; Byrne, Christopher D; Nanayakkara, Prabath W B; Papagianni, Aikaterini; Witham, Miles D; Bernal, Enrique; Ekart, Robert; van Agtmael, Michiel A; Neves, Mario F; Sato, Eiichi; Ezhov, Marat; Walters, Matthew; Olsen, Michael H; Stolic, Radojica; Zozulinska-Ziólkiewicz, Dorota A; Hanefeld, Markolf; Staub, Daniel; Nagai, Michiaki; Nieuwkerk, Pythia T; Huisman, Menno V; Kato, Akihiko; Honda, Hirokazu; Parraga, Grace; Magliano, Dianna; Gabriel, Rafael; Rundek, Tatjana; Espeland, Mark A; Kiechl, Stefan; Willeit, Johann.
Afiliação
  • Tschiderer L; Department of Neurology, Medical University of Innsbruck, Innsbruck, Austria.
  • Seekircher L; Department of Neurology, Medical University of Innsbruck, Innsbruck, Austria.
  • Klingenschmid G; Department of Neurology, Medical University of Innsbruck, Innsbruck, Austria.
  • Izzo R; Department of Advanced Biochemical Sciences, Federico II University, Naples, Italy.
  • Baldassarre D; Department of Medical Biotechnology and Translational Medicine, University of Milan, Milan, Italy.
  • Iglseder B; Centro Cardiologico Monzino IRCCS, Milan, Italy.
  • Calabresi L; Department of Geriatric Medicine, Gemeinnützige Salzburger Landeskliniken Betriebsgesellschaft GmbH Christian-Doppler-Klinik, Salzburg, Austria.
  • Liu J; Department of Geriatric Medicine, Paracelsus Medical University, Salzburg, Austria.
  • Price JF; Department of Pharmacological and Biomolecular Sciences, University of Milan, Milan, Italy.
  • Bae JH; Department of Epidemiology, Beijing Anzhen Hospital, Capital Medical University, Beijing, China.
  • Brouwers FP; Usher Institute, University of Edinburgh, Edinburgh, United Kingdom.
  • de Groot E; Heart Center, Konyang University Hospital, Daejeon, Republic of Korea.
  • Schmidt C; Department of Cardiology, Konyang University College of Medicine, Daejeon, Republic of Korea.
  • Bergström G; Department of Cardiology, Haga Teaching Hospital, The Hague, The Netherlands.
  • Asçi G; Imagelabonline and Cardiovascular, Eindhoven/Lunteren, The Netherlands.
  • Gresele P; Wallenberg Laboratory for Cardiovascular Research, University of Gothenburg, Gothenburg, Sweden.
  • Okazaki S; Department of Molecular and Clinical Medicine, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.
  • Kapellas K; Department of Clinical Physiology, Sahlgrenska University Hospital, Region Västra Götaland, Gothenburg, Sweden.
  • Landecho MF; Nephrology Department, Ege University School of Medicine, Bornova-Izmir, Turkey.
  • Sattar N; Division of Internal and Cardiovascular Medicine, Department of Medicine, University of Perugia, Perugia, Italy.
  • Agewall S; Department of Neurology, Osaka University Graduate School of Medicine, Osaka, Japan.
  • Zou ZY; Australian Research Centre for Population Oral Health, University of Adelaide, Adelaide, South Australia, Australia.
  • Byrne CD; Department of Internal Medicine, University Clinic of Navarra, Navarra, Spain.
  • Nanayakkara PWB; BHF Glasgow Cardiovascular Research Centre, University of Glasgow, Glasgow, United Kingdom.
  • Papagianni A; Oslo University Hospital Ullevål and Institute of Clinical Sciences, University of Oslo, Oslo, Norway.
  • Witham MD; Institute of Child and Adolescent Health, School of Public Health, Peking University, Beijing, China.
  • Bernal E; Human Development and Health Academic Unit, Faculty of Medicine, The Institute of Developmental Sciences, University of Southampton - Southampton General Hospital, Southampton, United Kingdom.
  • Ekart R; Department of Clinical Neurophysiology, Amsterdam UMC, Amsterdam, The Netherlands.
  • van Agtmael MA; University Department of Nephrology, Hippokration General Hospital, Thessaloniki, Greece.
  • Neves MF; AGE Research Group, NIHR Newcastle Biomedical Research Centre, Newcastle University and Newcastle-upon-Tyne Hospitals Trust, Newcastle, United Kingdom.
  • Sato E; Infectious Diseases Unit, Reina Sofia Hospital, Murcia, Spain.
  • Ezhov M; Department of Dialysis, University Medical Centre Maribor, Maribor, Slovenia.
  • Walters M; Department of Internal Medicine Amsterdam UMC, Vrije Universiteit, Amsterdam, The Netherlands.
  • Olsen MH; Department of Clinical Medicine, State University of Rio de Janeiro, Rio de Janeiro, Brazil.
  • Stolic R; Division of Nephrology, Shinmatsudo Central General Hospital, Chiba, Japan.
  • Zozulinska-Ziólkiewicz DA; Laboratory of Lipid Disorders, National Medical Research Center of Cardiology, Moscow, Russian Federation.
  • Hanefeld M; School of Medicine, Dentistry and Nursing, University of Glasgow, Glasgow, United Kingdom.
  • Staub D; Department of Internal Medicine, Holbaek Hospital, University of Southern Denmark, Odense, Denmark.
  • Nagai M; Department of Internal Medicine, Faculty of Medical Sciences, University of Kragujevac, Kragujevac, Serbia.
  • Nieuwkerk PT; Department of Internal Medicine and Diabetology, Poznan University of Medical Sciences, Poznan, Poland.
  • Huisman MV; Center for Clinical Studies, Technical University Dresden, Dresden, Germany.
  • Kato A; Department of Angiology, University Hospital Basel, Basel, Switzerland.
  • Honda H; Department of Internal Medicine, General Medicine and Cardiology, Hiroshima City Asa Hospital, Hiroshima, Japan.
  • Parraga G; Department of Medical Psychology, Amsterdam UMC - Location AMC, Amsterdam, The Netherlands.
  • Magliano D; Department of Thrombosis and Hemostasis, Leiden University Medical Center, Leiden, The Netherlands.
  • Gabriel R; Blood Purification Unit, Hamamatsu University Hospital, Hamamatsu, Japan.
  • Rundek T; Division of Nephrology, Department of Medicine, Showa University School of Medicine, Tokyo, Japan.
  • Espeland MA; Department of Medical Biophysics, Western University, London, Ontario, Canada.
  • Kiechl S; Department of Epidemiology and Preventive Medicine, Monash University, Alfred Hospital, Melbourne, Victoria, Australia.
  • Willeit J; National School of Public Health, Instituto de Salud Carlos III, Madrid, Spain.
Gerontology ; 66(5): 447-459, 2020.
Article em En | MEDLINE | ID: mdl-32610336
ABSTRACT
Atherosclerosis - the pathophysiological mechanism shared by most cardiovascular diseases - can be directly or indirectly assessed by a variety of clinical tests including measurement of carotid intima-media thickness, carotid plaque, -ankle-brachial index, pulse wave velocity, and coronary -artery calcium. The Prospective Studies of Atherosclerosis -(Proof-ATHERO) consortium (https//clinicalepi.i-med.ac.at/research/proof-athero/) collates de-identified individual-participant data of studies with information on atherosclerosis measures, risk factors for cardiovascular disease, and incidence of cardiovascular diseases. It currently comprises 74 studies that involve 106,846 participants from 25 countries and over 40 cities. In summary, 21 studies recruited participants from the general population (n = 67,784), 16 from high-risk populations (n = 22,677), and 37 as part of clinical trials (n = 16,385). Baseline years of contributing studies range from April 1980 to July 2014; the latest follow-up was until June 2019. Mean age at baseline was 59 years (standard deviation 10) and 50% were female. Over a total of 830,619 person-years of follow-up, 17,270 incident cardiovascular events (including coronary heart disease and stroke) and 13,270 deaths were recorded, corresponding to cumulative incidences of 2.1% and 1.6% per annum, respectively. The consortium is coordinated by the Clinical Epidemiology Team at the Medical University of Innsbruck, Austria. Contributing studies undergo a detailed data cleaning and harmonisation procedure before being incorporated in the Proof-ATHERO central database. Statistical analyses are being conducted according to pre-defined analysis plans and use established methods for individual-participant data meta-analysis. Capitalising on its large sample size, the multi-institutional collaborative Proof-ATHERO consortium aims to better characterise, understand, and predict the development of atherosclerosis and its clinical consequences.
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Aterosclerose Tipo de estudo: Etiology_studies / Observational_studies / Prognostic_studies / Risk_factors_studies / Systematic_reviews Limite: Aged / Female / Humans / Male / Middle aged Idioma: En Ano de publicação: 2020 Tipo de documento: Article

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Aterosclerose Tipo de estudo: Etiology_studies / Observational_studies / Prognostic_studies / Risk_factors_studies / Systematic_reviews Limite: Aged / Female / Humans / Male / Middle aged Idioma: En Ano de publicação: 2020 Tipo de documento: Article