A genome-wide and cotranscriptional suppressor of R loops.
Genes Dev
; 34(13-14): 863-864, 2020 07 01.
Article
em En
| MEDLINE
| ID: mdl-32611612
ABSTRACT
R loops arise from hybridization of RNA transcripts with template DNA during transcription. Unrepaired R loops lead to transcription-replication collisions, causing DNA damage and genomic instability. In this issue of Genes & Development, Pérez-Calero and colleagues (pp. 898-912) identify UAP56 as a cotranscriptional RNA-DNA helicase that unwinds R loops. They found that UAP56 helicase activity is required to remove R loops formed from different sources and prevent R-loop accumulation genome-wide at actively transcribed genes.
Palavras-chave
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Transcrição Gênica
/
Genoma
/
Estruturas R-Loop
Limite:
Humans
Idioma:
En
Ano de publicação:
2020
Tipo de documento:
Article