Interleukin 2 increases protection against experimental rabies.
Immunobiology
; 177(2): 199-209, 1988 May.
Article
em En
| MEDLINE
| ID: mdl-3261273
ABSTRACT
Vaccination with either whole inactivated rabies virus or immunosome (rabies glycoprotein anchored on liposomes) induces a high level of interleukin 2 (IL 2) production after in vitro specific stimulation of splenocytes from primed mice (9). On the contrary, infection with a live rabies virus does not specifically induce the production of IL 2 splenocytes from ill mice previously infected with wild rabies virus cannot be specifically stimulated by rabies antigens, whereas they can be non-specifically stimulated by a mitogen (Concanavalin A (Con A]. When injected in mice, exogenous IL 2 (purified rat IL 2 or human recombinant IL 2) exhibits an adjuvant effect on rabies virus vaccine or subunit vaccine tested in a pre-exposure potency test (NIH test). When injected in hamsters, according to a post-exposure potency test (infection with a wild rabies virus followed by vaccination), IL 2 has no adjuvant effect on the rabies vaccine. Nevertheless, when injected alone, IL 2 protects thirty to fifty percent of the infected animals treated (1 hour, 3 and 7 days post-infection) with 10 international units of human recombinant IL 2.
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Base de dados:
MEDLINE
Assunto principal:
Raiva
/
Vacina Antirrábica
/
Linfócitos
/
Interleucina-2
Limite:
Animals
Idioma:
En
Ano de publicação:
1988
Tipo de documento:
Article