Sex-Specific Effects of the Nlrp3 Inflammasome on Atherogenesis in LDL Receptor-Deficient Mice.

Chen, Shuang; Markman, Janet L; Shimada, Kenichi; Crother, Timothy R; Lane, Malcolm; Abolhesn, Amanda; Shah, Prediman K; Arditi, Moshe.

Afiliação

Chen S; Department of Biomedical Sciences, Infectious and Immunologic Diseases Research Center, Cedars-Sinai Medical Center, Los Angeles, California.
Markman JL; Department of Biomedical Sciences, Infectious and Immunologic Diseases Research Center, Cedars-Sinai Medical Center, Los Angeles, California.
Shimada K; Department of Biomedical Sciences, Infectious and Immunologic Diseases Research Center, Cedars-Sinai Medical Center, Los Angeles, California.
Crother TR; Department of Biomedical Sciences, Infectious and Immunologic Diseases Research Center, Cedars-Sinai Medical Center, Los Angeles, California.
Lane M; Department of Biomedical Sciences, Infectious and Immunologic Diseases Research Center, Cedars-Sinai Medical Center, Los Angeles, California.
Abolhesn A; Department of Biomedical Sciences, Infectious and Immunologic Diseases Research Center, Cedars-Sinai Medical Center, Los Angeles, California.
Shah PK; Department of Biomedical Sciences, Infectious and Immunologic Diseases Research Center, Cedars-Sinai Medical Center, Los Angeles, California.
Arditi M; Division of Cardiology, Department of Medicine, Oppenheimer Atherosclerosis Research Center, Smidt Heart Institute, Cedars-Sinai Medical Center, Los Angeles, California.

JACC Basic Transl Sci ; 5(6): 582-598, 2020 Jun.

Article em En | MEDLINE | ID: mdl-32613145

Palavras-chave

ACVD, atherosclerotic cardiovascular disease; BM, bone marrow; CAS, castration; ER, estrogen receptor; FLICA, fluorescent labeled inhibitors of caspases; HFD, high-fat diet; IL, interleukin; IL-1ß; NLRP3 inflammasome; NLRP3, nucleotide-binding domain and leucine-rich repeat containing (NLR) protein3; OVX, ovariectomy; atherosclerosis; sex

Texto completo: 1 Base de dados: MEDLINE Idioma: En Ano de publicação: 2020 Tipo de documento: Article

Texto completo: 1 Base de dados: MEDLINE Idioma: En Ano de publicação: 2020 Tipo de documento: Article