Association between the ACE I/D polymorphism and muscle injuries in Italian and Japanese elite football players.
J Sports Sci
; 38(21): 2423-2429, 2020 Nov.
Article
em En
| MEDLINE
| ID: mdl-32614675
ABSTRACT
ACE I/D polymorphism has been recently associated with the susceptibility to inflammation and muscle damage after exercise. The aim of this study was to understand the association between the ACE I/D polymorphism and muscle injuries in a large cohort of elite football players from two different countries. Seven hundred and ten male elite football players from Italy (n = 341) and Japan (n = 369) were recruited for the study. Genomic DNA was extracted from either the buccal epithelium or saliva using a standard protocol. Structural-mechanical injuries and functional muscle disorders were recorded from 2009 to 2018. A meta-analysis was performed using Review Manager 5.3.5. In the Japanese cohort, the ACE I/D polymorphism was significantly associated with muscle injury using the D-dominant model (OR 0.48, 95% CI 0.24-0.97, P = 0.040). The meta-analysis showed that in the pooled model (Italian and Japanese populations), the frequencies of the DD+ID genotypes were significantly lower in the injured groups than in non-injured groups (OR 0.61, 95% CI 0.38-0.98, P = 0.04) with a low degree of heterogeneity (I2 = 0%). Our findings suggest that the ACE I/D polymorphism could influence the susceptibility to developing muscle injuries among football players.
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Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Polimorfismo Genético
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Futebol
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Peptidil Dipeptidase A
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Músculo Esquelético
Tipo de estudo:
Prognostic_studies
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Risk_factors_studies
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Systematic_reviews
Limite:
Adult
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Humans
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Male
País como assunto:
Asia
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Europa
Idioma:
En
Ano de publicação:
2020
Tipo de documento:
Article