Design, synthesis, and antitumor activity of novel compounds based on 1,2,4-triazolophthalazine scaffold: Apoptosis-inductive and PCAF-inhibitory effects.

Turky, Abdallah; Bayoumi, Ashraf H; Ghiaty, Adel; El-Azab, Adel S; A-M Abdel-Aziz, Alaa; Abulkhair, Hamada S

Turky, Abdallah; Bayoumi, Ashraf H; Ghiaty, Adel; El-Azab, Adel S; A-M Abdel-Aziz, Alaa; Abulkhair, Hamada S.

Afiliação

Turky A; Department of Pharmaceutical Organic Chemistry, Faculty of Pharmacy, Al-Azhar University, Nasr City 11884, Cairo, Egypt.
Bayoumi AH; Department of Pharmaceutical Organic Chemistry, Faculty of Pharmacy, Al-Azhar University, Nasr City 11884, Cairo, Egypt.
Ghiaty A; Department of Pharmaceutical Organic Chemistry, Faculty of Pharmacy, Al-Azhar University, Nasr City 11884, Cairo, Egypt.
El-Azab AS; Department of Pharmaceutical Chemistry, College of Pharmacy, King Saud University, P.O. Box 2457, Riyadh 11451, Saudi Arabia.
A-M Abdel-Aziz A; Department of Pharmaceutical Chemistry, College of Pharmacy, King Saud University, P.O. Box 2457, Riyadh 11451, Saudi Arabia. Electronic address: almoenes@ksu.edu.sa.
Abulkhair HS; Department of Pharmaceutical Organic Chemistry, Faculty of Pharmacy, Al-Azhar University, Nasr City 11884, Cairo, Egypt; Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Horus University - Egypt, International Costal Road, New Damietta, Egypt. Electronic address: hamadaorganic@azhar.edu.

Bioorg Chem ; 101: 104019, 2020 08.

Article em En | MEDLINE | ID: mdl-32615465

Assuntos

Antineoplásicos/química; Antineoplásicos/farmacologia; Apoptose/efeitos dos fármacos; Desenho de Fármacos; Ftalazinas/química; Ftalazinas/farmacologia; Triazóis/química; Fatores de Transcrição de p300-CBP/antagonistas & inibidores; Antineoplásicos/síntese química; Ciclo Celular; Ensaios de Seleção de Medicamentos Antitumorais; Humanos; Células MCF-7; Simulação de Acoplamento Molecular; Ftalazinas/síntese química; Relação Estrutura-Atividade

Palavras-chave

1,2,4-triazolophthalazine scaffold; Antitumor activity; Apoptosis induction; PCAF-inhibition; Synthesis

Texto completo

Imprimir

XML

PubMed Links

Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Ftalazinas / Triazóis / Desenho de Fármacos / Apoptose / Fatores de Transcrição de p300-CBP / Antineoplásicos Tipo de estudo: Prognostic_studies Limite: Humans Idioma: En Ano de publicação: 2020 Tipo de documento: Article

Texto completo

Imprimir

XML

PubMed Links

Buscar no Google