Formylation of a metathesis-derived ansa[4]-ferrocene: a simple route to anticancer organometallics.
Dalton Trans
; 49(33): 11504-11511, 2020 Aug 25.
Article
em En
| MEDLINE
| ID: mdl-32627790
ABSTRACT
Formylation of ansa[4]-ferrocene, obtained through the ruthenium-catalysed olefin metathesis, yields two separable, planar chiral 1,3- and 1,2-ansa-ferrocene aldehydes. Single-crystal X-ray structure analysis reveals that both regioisomers crystallize with spontaneous resolution of the racemate in the chiral P212121 space group with one molecule in the asymmetric unit. The major 1,3-isomer was further transformed into a conjugate with 1,2,3-triazole and uracil using "click" chemistry as the key synthetic step. This inorganic-organic hybrid displays anticancer activity (MCF-7, A549, MDA-MB-231 cell lines) with EC50 values comparable to those for cisplatin.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Compostos Ferrosos
/
Complexos de Coordenação
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Metalocenos
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Antineoplásicos
Limite:
Humans
Idioma:
En
Ano de publicação:
2020
Tipo de documento:
Article