Your browser doesn't support javascript.
loading
Hepatotoxicity of graphene oxide in Wistar rats.
Nirmal, Naresh K; Awasthi, Kumud K; John, Placheril J.
Afiliação
  • Nirmal NK; Department of Zoology, University of Rajasthan, Jaipur, 302004, India.
  • Awasthi KK; Department of Life Sciences, Vivekananda Global University, Jaipur, 303012, India.
  • John PJ; Department of Zoology, University of Rajasthan, Jaipur, 302004, India. placheriljohn@gmail.com.
Environ Sci Pollut Res Int ; 28(34): 46367-46376, 2021 Sep.
Article em En | MEDLINE | ID: mdl-32632678
Graphene oxide (GO) has a multitude of applications in areas of nanomedicine, electronics, textile, water purification, and catalysis among others. GO is relatively easier to manufacture and customize as compared with other carbon-based nanomaterials. In the present work, GO was administered intraperitoneally to adult Wistar rats in four incremental doses, i.e., 0.0 mg/kg (control), 0.4 mg/kg (low dose), 2.0 mg/kg (mid-dose), and 10.0 mg/kg (high dose). After 15 repeated doses over a period of 30 days, biochemical assays for alanine transaminase (ALT), aspartate transaminase (AST), alkaline phosphatase (ALP), catalase (CAT), and malondialdehyde (MDA) were carried out. Histopathological and morphometric analyses of liver and kidney were also performed. Results demonstrated dose-dependent toxicity of GO. General behavior and liver indices remained unaffected in the study. Serum levels of ALT, ALP, and AST were altered significantly in high-dose treated animals. Changes were found insignificant in the low- and mid-dose groups. Catalase activity in liver tissue homogenates was decreased in the high-dose group. MDA levels were found elevated in treated rats. Unlike control and low dose, mid- and high-dose treated rats exhibited varying degrees of histopathological changes like inflammation around the central vein and portal veins, vacuolations, hepatocytic injury, and near normal to abnormal hepatic sinusoids. These findings show that GO has considerable toxic potential to mammalian liver and thorough toxicity studies are needed before these nanosheets are used in biomedicine.
Assuntos
Palavras-chave

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Doença Hepática Induzida por Substâncias e Drogas / Grafite / Fígado Limite: Animals Idioma: En Ano de publicação: 2021 Tipo de documento: Article

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Doença Hepática Induzida por Substâncias e Drogas / Grafite / Fígado Limite: Animals Idioma: En Ano de publicação: 2021 Tipo de documento: Article