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Regulatory systems that mediate the effects of temperature on the lifespan of Caenorhabditis elegans.
Kim, Byounghun; Lee, Jongsun; Kim, Younghun; Lee, Seung-Jae V.
Afiliação
  • Kim B; Department of Biological Sciences, Korea Advanced Institute of Science and Technology, Daejeon, South Korea.
  • Lee J; Department of Biological Sciences, Korea Advanced Institute of Science and Technology, Daejeon, South Korea.
  • Kim Y; Department of Biological Sciences, Korea Advanced Institute of Science and Technology, Daejeon, South Korea.
  • Lee SV; Department of Biological Sciences, Korea Advanced Institute of Science and Technology, Daejeon, South Korea.
J Neurogenet ; 34(3-4): 518-526, 2020.
Article em En | MEDLINE | ID: mdl-32633588
Temperature affects animal physiology, including aging and lifespan. How temperature and biological systems interact to influence aging and lifespan has been investigated using model organisms, including the nematode Caenorhabditis elegans. In this review, we discuss mechanisms by which diverse cellular factors modulate the effects of ambient temperatures on aging and lifespan in C. elegans. C. elegans thermosensory neurons alleviate lifespan-shortening effects of high temperatures via sterol endocrine signaling and probably through systemic regulation of cytosolic proteostasis. At low temperatures, C. elegans displays a long lifespan by upregulating the cold-sensing TRPA channel, lipid homeostasis, germline-mediated prostaglandin signaling, and autophagy. In addition, co-chaperone p23 amplifies lifespan changes affected by high and low temperatures. Our review summarizes how external temperatures modulate C. elegans lifespan and provides information regarding responses of biological processes to temperature changes, which may affect health and aging at an organism level.
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Temperatura / Caenorhabditis elegans / Longevidade Tipo de estudo: Prognostic_studies Limite: Animals Idioma: En Ano de publicação: 2020 Tipo de documento: Article

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Temperatura / Caenorhabditis elegans / Longevidade Tipo de estudo: Prognostic_studies Limite: Animals Idioma: En Ano de publicação: 2020 Tipo de documento: Article