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The immunogenetic diversity of the HLA system in Mexico correlates with underlying population genetic structure.
Barquera, Rodrigo; Hernández-Zaragoza, Diana Iraíz; Bravo-Acevedo, Alicia; Arrieta-Bolaños, Esteban; Clayton, Stephen; Acuña-Alonzo, Víctor; Martínez-Álvarez, Julio César; López-Gil, Concepción; Adalid-Sáinz, Carmen; Vega-Martínez, María Del Rosario; Escobedo-Ruíz, Araceli; Juárez-Cortés, Eva Dolores; Immel, Alexander; Pacheco-Ubaldo, Hanna; González-Medina, Liliana; Lona-Sánchez, Abraham; Lara-Riegos, Julio; Sánchez-Fernández, María Guadalupe de Jesús; Díaz-López, Rosario; Guizar-López, Gregorio Ulises; Medina-Escobedo, Carolina Elizabeth; Arrazola-García, María Araceli; Montiel-Hernández, Gustavo Daniel; Hernández-Hernández, Ofelia; Ramos-de la Cruz, Flor Del Rocío; Juárez-Nicolás, Francisco; Pantoja-Torres, Jorge Arturo; Rodríguez-Munguía, Tirzo Jesús; Juárez-Barreto, Vicencio; Delgado-Aguirre, Héctor; Escutia-González, Ariadna Berenice; Goné-Vázquez, Isis; Benítez-Arvizu, Gamaliel; Arellano-Prado, Francia Paulina; García-Arias, Víctor Eduardo; Rodríguez-López, Marla Estefanía; Méndez-Mani, Patricia; García-Álvarez, Raquel; González-Martínez, Marisela Del Rocío; Aquino-Rubio, Guadalupe; Escareño-Montiel, Néstor; Vázquez-Castillo, Tannya Verónica; Uribe-Duarte, María Guadalupe; Ruíz-Corral, María de Jesús; Ortega-Yáñez, Andrea; Bernal-Felipe, Natalia; Gómez-Navarro, Benjamín; Arriaga-Perea, Agustín Jericó; Martínez-Bezies, Virginia; Macías-Medrano, Rosa María.
Afiliação
  • Barquera R; Department of Archaeogenetics, Max Planck Institute for the Science of Human History (MPI-SHH), Jena, Germany; Molecular Genetics Laboratory, Escuela Nacional de Antropología e Historia (ENAH), Mexico City, Mexico. Electronic address: barquera@shh.mpg.de.
  • Hernández-Zaragoza DI; Molecular Genetics Laboratory, Escuela Nacional de Antropología e Historia (ENAH), Mexico City, Mexico; Immunogenetics Unit, Técnicas Genéticas Aplicadas a la Clínica (TGAC), Mexico City, Mexico.
  • Bravo-Acevedo A; Blood Bank, UMAE Hospital de Gineco Obstetricia No. 4 "Luis Castelazo Ayala", Instituto Mexicano del Seguro Social (IMSS), Mexico City, Mexico.
  • Arrieta-Bolaños E; Institute for Experimental Cellular Therapy, University Hospital Essen, Essen, Germany.
  • Clayton S; Department of Archaeogenetics, Max Planck Institute for the Science of Human History (MPI-SHH), Jena, Germany.
  • Acuña-Alonzo V; Molecular Genetics Laboratory, Escuela Nacional de Antropología e Historia (ENAH), Mexico City, Mexico.
  • Martínez-Álvarez JC; HLA Laboratory, Central Blood Bank, Hospital de Especialidades, Unidad Médica de Alta Especialidad (UMAE), Centro Médico Nacional "Siglo XXI", Instituto Mexicano del Seguro Social (IMSS), Mexico City, Mexico.
  • López-Gil C; Histocompatibility Laboratory, Unidad Médica de Alta Especialidad (UMAE) # 6, Instituto Mexicano del Seguro Social (IMSS), Puebla, Puebla, Mexico.
  • Adalid-Sáinz C; Laboratory of Histocompatibility, Unidad Médica de Alta Especialidad (UMAE) # 71, Instituto Mexicano del Seguro Social (IMSS), Torreón, Coahuila, Mexico.
  • Vega-Martínez MDR; Molecular Biology and Histocompatibility Laboratory, Hospital Central Sur de Alta Especialidad, Petróleos Mexicanos (PEMEX), Mexico City, Mexico.
  • Escobedo-Ruíz A; Histocompatibility Laboratory, Hospital de Especialidades, Centro Médico Nacional de Occidente (CMNO), Instituto Mexicano del Seguro Social (IMSS), Guadalajara, Jalisco, Mexico.
  • Juárez-Cortés ED; Histocompatibility Laboratory, Central Blood Bank, Centro Médico Nacional "La Raza", Instituto Mexicano del Seguro Social (IMSS), Mexico City, Mexico.
  • Immel A; Department of Archaeogenetics, Max Planck Institute for the Science of Human History (MPI-SHH), Jena, Germany; Institute of Clinical Molecular Biology (IKMB), Kiel University, University Hospital, Schleswig-Holstein, Germany.
  • Pacheco-Ubaldo H; Molecular Genetics Laboratory, Escuela Nacional de Antropología e Historia (ENAH), Mexico City, Mexico.
  • González-Medina L; Molecular Genetics Laboratory, Escuela Nacional de Antropología e Historia (ENAH), Mexico City, Mexico.
  • Lona-Sánchez A; Molecular Genetics Laboratory, Escuela Nacional de Antropología e Historia (ENAH), Mexico City, Mexico.
  • Lara-Riegos J; Chemistry Faculty, Universidad Autónoma de Yucatán (UADY), Mérida, Yucatán, Mexico.
  • Sánchez-Fernández MGJ; Department of Nephrology and Transplantation Unit, Centro Médico Nacional de Occidente (CMNO), Instituto Mexicano del Seguro Social (IMSS), Guadalajara, Jalisco, Mexico.
  • Díaz-López R; Molecular Biology Laboratory, Hospital Central Militar, Secretaría de la Defensa Nacional (SEDENA), Mexico City, Mexico.
  • Guizar-López GU; Molecular Biology Laboratory, Hospital Central Militar, Secretaría de la Defensa Nacional (SEDENA), Mexico City, Mexico.
  • Medina-Escobedo CE; Unit of Research and Education in Health, Unidad Médica de Alta Especialidad (UMAE) # 10, Instituto Mexicano del Seguro Social (IMSS), Mérida, Yucatán, Mexico.
  • Arrazola-García MA; HLA Laboratory, Central Blood Bank, Hospital de Especialidades, Unidad Médica de Alta Especialidad (UMAE), Centro Médico Nacional "Siglo XXI", Instituto Mexicano del Seguro Social (IMSS), Mexico City, Mexico.
  • Montiel-Hernández GD; Escuela Nacional de Antropología e Historia (ENAH), Mexico City, Mexico.
  • Hernández-Hernández O; Immunogenetics Unit, Técnicas Genéticas Aplicadas a la Clínica (TGAC), Mexico City, Mexico.
  • Ramos-de la Cruz FDR; Histocompatibility Laboratory, Unidad Médica de Alta Especialidad (UMAE) # 6, Instituto Mexicano del Seguro Social (IMSS), Puebla, Puebla, Mexico.
  • Juárez-Nicolás F; Molecular Immunogenetics Laboratory, Instituto Nacional de Pediatría (INP), Mexico City, Mexico.
  • Pantoja-Torres JA; Immunology Division, Unidad Médica de Alta Especialidad (UMAE) # 1, Instituto Mexicano del Seguro Social (IMSS), León, Guanajuato, Mexico.
  • Rodríguez-Munguía TJ; Molecular Biology Laboratory, Hospital General "Norberto Treviño Zapata", Dirección de Servicios de Salud de Tamaulipas, Ciudad Victoria, Tamaulipas, Mexico.
  • Juárez-Barreto V; Blood Bank, Hospital Infantil de México "Federico Gómez", Mexico City, Mexico.
  • Delgado-Aguirre H; Laboratory of Histocompatibility, Unidad Médica de Alta Especialidad (UMAE) # 71, Instituto Mexicano del Seguro Social (IMSS), Torreón, Coahuila, Mexico.
  • Escutia-González AB; Molecular Immunogenetics Laboratory, Instituto Nacional de Pediatría (INP), Mexico City, Mexico.
  • Goné-Vázquez I; Histocompatibility Laboratory, Hospital de Especialidades, Centro Médico Nacional de Occidente (CMNO), Instituto Mexicano del Seguro Social (IMSS), Guadalajara, Jalisco, Mexico.
  • Benítez-Arvizu G; HLA Laboratory, Central Blood Bank, Hospital de Especialidades, Unidad Médica de Alta Especialidad (UMAE), Centro Médico Nacional "Siglo XXI", Instituto Mexicano del Seguro Social (IMSS), Mexico City, Mexico.
  • Arellano-Prado FP; Pediatrics Hospital, Centro Médico Nacional de Occidente (CMNO), Instituto Mexicano del Seguro Social (IMSS), Guadalajara, Jalisco, Mexico.
  • García-Arias VE; Pediatrics Hospital, Centro Médico Nacional de Occidente (CMNO), Instituto Mexicano del Seguro Social (IMSS), Guadalajara, Jalisco, Mexico.
  • Rodríguez-López ME; Pediatrics Hospital, Centro Médico Nacional de Occidente (CMNO), Instituto Mexicano del Seguro Social (IMSS), Guadalajara, Jalisco, Mexico.
  • Méndez-Mani P; Histocompatibility Laboratory, Unidad Médica de Alta Especialidad (UMAE) # 6, Instituto Mexicano del Seguro Social (IMSS), Puebla, Puebla, Mexico.
  • García-Álvarez R; Pharmacology Laboratory, Research Unit, Instituto Nacional de Pediatría (INP), Mexico City, Mexico.
  • González-Martínez MDR; Microbiology Department, Faculty of Medicine, Universidad Autónoma de Coahuila, Torreón, Coahuila, Mexico.
  • Aquino-Rubio G; Molecular Biology Laboratory, Hospital General "Norberto Treviño Zapata", Dirección de Servicios de Salud de Tamaulipas, Ciudad Victoria, Tamaulipas, Mexico.
  • Escareño-Montiel N; Department of Transplantation, Unidad Médica de Alta Especialidad (UMAE) # 71, Instituto Mexicano del Seguro Social (IMSS), Torreón, Coahuila, Mexico.
  • Vázquez-Castillo TV; Department of Molecular Biology, Laboratorios Diagnóstica, Villahermosa, Tabasco, Mexico.
  • Uribe-Duarte MG; Clinical Laboratory, Unidad Médica de Alta Especialidad (UMAE) # 2, Instituto Mexicano del Seguro Social (IMSS), Ciudad Obregón, Sonora, Mexico.
  • Ruíz-Corral MJ; Clinical Laboratory, Unidad Médica de Alta Especialidad (UMAE) # 2, Instituto Mexicano del Seguro Social (IMSS), Ciudad Obregón, Sonora, Mexico.
  • Ortega-Yáñez A; Department of Development Genetics and Molecular Physiology, Instituto de Biotecnología (IBT), Universidad Nacional Autónoma de México (UNAM), Cuernavaca, Morelos, Mexico.
  • Bernal-Felipe N; Escuela Nacional de Antropología e Historia (ENAH), Mexico City, Mexico.
  • Gómez-Navarro B; Central Office of Nephrology, Centro Médico Nacional de Occidente (CMNO), Instituto Mexicano del Seguro Social (IMSS), Guadalajara, Jalisco, Mexico.
  • Arriaga-Perea AJ; Histocompatibility Laboratory, Central Blood Bank, Centro Médico Nacional "La Raza", Instituto Mexicano del Seguro Social (IMSS), Mexico City, Mexico.
  • Martínez-Bezies V; Molecular Immunogenetics Laboratory, Instituto Nacional de Pediatría (INP), Mexico City, Mexico.
  • Macías-Medrano RM; Histocompatibility Laboratory, Central Blood Bank, Centro Médico Nacional "La Raza", Instituto Mexicano del Seguro Social (IMSS), Mexico City, Mexico.
Hum Immunol ; 81(9): 461-474, 2020 Sep.
Article em En | MEDLINE | ID: mdl-32651014
ABSTRACT
We studied HLA class I (HLA-A, -B) and class II (HLA-DRB1, -DQB1) allele groups and alleles by PCR-SSP based typing in a total of 15,318 mixed ancestry Mexicans from all the states of the country divided into 78 sample sets, providing information regarding allelic and haplotypic frequencies and their linkage disequilibrium, as well as admixture estimates and genetic substructure. We identified the presence of 4268 unique HLA extended haplotypes across Mexico and find that the ten most frequent (HF > 1%) HLA haplotypes with significant linkage disequilibrium (Δ'≥0.1) in Mexico (accounting for 20% of the haplotypic diversity of the country) are of primarily Native American ancestry (A*02~B*39~DRB1*04~DQB1*0302, A*02~B*35~DRB1*08~DQB1*04, A*68~B*39~DRB1*04~DQB1*0302, A*02~B*35~DRB1*04~DQB1*0302, A*24~B*39~DRB1*14~DQB1*0301, A*24~B*35~DRB1*04~DQB1*0302, A*24~B*39~DRB1*04~DQB1*0302, A*02~B*4002~DRB1*04~DQB1*0302, A*68~B*35~DRB1*04~DQB1*0302, A*02~B*1501~DRB1*04~DQB1*0302). Admixture estimates obtained by a maximum likelihood method using HLA-A/-B/-DRB1 as genetic estimators revealed that the main genetic components in Mexico as a whole are Native American (ranging from 37.8% in the northern part of the country to 81.5% in the southeastern region) and European (ranging from 11.5% in the southeast to 62.6% in northern Mexico). African admixture ranged from 0.0 to 12.7% not following any specific pattern. We were able to detect three major immunogenetic clusters correlating with genetic diversity and differential admixture within Mexico North, Central and Southeast, which is in accordance with previous reports using genome-wide data. Our findings provide insights into the population immunogenetic substructure of the whole country and add to the knowledge of mixed ancestry Latin American population genetics, important for disease association studies, detection of demographic signatures on population variation and improved allocation of public health resources.
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Polimorfismo de Nucleotídeo Único / Alelos / Genética Populacional / Antígenos HLA / Complexo Principal de Histocompatibilidade Tipo de estudo: Prognostic_studies Limite: Humans País como assunto: Mexico Idioma: En Ano de publicação: 2020 Tipo de documento: Article

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Polimorfismo de Nucleotídeo Único / Alelos / Genética Populacional / Antígenos HLA / Complexo Principal de Histocompatibilidade Tipo de estudo: Prognostic_studies Limite: Humans País como assunto: Mexico Idioma: En Ano de publicação: 2020 Tipo de documento: Article