Thymopentin improves the survival of septic mice by promoting the production of 15-deoxy-prostaglandin J2 and activating the PPARÎ³ signaling pathway.

Zhang, Ye; Yang, Xue; Yan, Wenchao; Li, Rui; Ye, Qian; You, Linjun; Xie, Wenhao; Mo, Kun; Fu, Ruifeng; Wang, Yanxiang; Chen, Yufei; Hou, Hui; Yang, Yong; Birnbaumer, Lutz; Di, Qin; Li, Xianjing

Zhang, Ye; Yang, Xue; Yan, Wenchao; Li, Rui; Ye, Qian; You, Linjun; Xie, Wenhao; Mo, Kun; Fu, Ruifeng; Wang, Yanxiang; Chen, Yufei; Hou, Hui; Yang, Yong; Birnbaumer, Lutz; Di, Qin; Li, Xianjing.

Afiliação

Zhang Y; Center for New Drug Safety Evaluation and Research, State Key Laboratory of Natural Medicines, China Pharmaceutical University, Nanjing, China.
Yang X; Center for New Drug Safety Evaluation and Research, State Key Laboratory of Natural Medicines, China Pharmaceutical University, Nanjing, China.
Yan W; Center for New Drug Safety Evaluation and Research, State Key Laboratory of Natural Medicines, China Pharmaceutical University, Nanjing, China.
Li R; Center for New Drug Safety Evaluation and Research, State Key Laboratory of Natural Medicines, China Pharmaceutical University, Nanjing, China.
Ye Q; Center for New Drug Safety Evaluation and Research, State Key Laboratory of Natural Medicines, China Pharmaceutical University, Nanjing, China.
You L; Center for New Drug Safety Evaluation and Research, State Key Laboratory of Natural Medicines, China Pharmaceutical University, Nanjing, China.
Xie W; Center for New Drug Safety Evaluation and Research, State Key Laboratory of Natural Medicines, China Pharmaceutical University, Nanjing, China.
Mo K; Center for New Drug Safety Evaluation and Research, State Key Laboratory of Natural Medicines, China Pharmaceutical University, Nanjing, China.
Fu R; Center for New Drug Safety Evaluation and Research, State Key Laboratory of Natural Medicines, China Pharmaceutical University, Nanjing, China.
Wang Y; Center for New Drug Safety Evaluation and Research, State Key Laboratory of Natural Medicines, China Pharmaceutical University, Nanjing, China.
Chen Y; Center for New Drug Safety Evaluation and Research, State Key Laboratory of Natural Medicines, China Pharmaceutical University, Nanjing, China.
Hou H; Center for New Drug Safety Evaluation and Research, State Key Laboratory of Natural Medicines, China Pharmaceutical University, Nanjing, China.
Yang Y; Center for New Drug Safety Evaluation and Research, State Key Laboratory of Natural Medicines, China Pharmaceutical University, Nanjing, China.
Birnbaumer L; Institute of Biomedical Research (BIOMED), Catholic University of Argentina, Buenos Aires, Argentina.
Di Q; School of Sports and Health, Nanjing Sport Institute, Nanjing, China.
Li X; Center for New Drug Safety Evaluation and Research, State Key Laboratory of Natural Medicines, China Pharmaceutical University, Nanjing, China.

FASEB J ; 34(9): 11772-11785, 2020 09.

Article em En | MEDLINE | ID: mdl-32652815

Assuntos

PPAR gama/metabolismo; Prostaglandina D2/análogos & derivados; Sepse/metabolismo; Transdução de Sinais/efeitos dos fármacos; Timopentina/farmacologia; Animais; Ceco/cirurgia; Citocinas/metabolismo; Mediadores da Inflamação/metabolismo; Ligadura/efeitos adversos; Masculino; Camundongos Endogâmicos C57BL; Prostaglandina D2/metabolismo; Punções/efeitos adversos; Sepse/etiologia; Sepse/mortalidade; Taxa de Sobrevida

Palavras-chave

15-d-PGJ2; PPARÎ³; macrophage; sepsis; thymopentin

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Prostaglandina D2 / Transdução de Sinais / Timopentina / Sepse / PPAR gama Tipo de estudo: Etiology_studies Limite: Animals Idioma: En Ano de publicação: 2020 Tipo de documento: Article

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