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A transcriptomic continuum of differentiation arrest identifies myeloid interface acute leukemias with poor prognosis.
Bond, Jonathan; Krzywon, Aleksandra; Lhermitte, Ludovic; Roumier, Christophe; Roggy, Anne; Belhocine, Mohamed; Kheirallah, Alexander Abdulkader; Villarese, Patrick; Hypolite, Guillaume; Garnache-Ottou, Francine; Castaigne, Sylvie; Boissel, Nicolas; Asnafi, Vahid; Preudhomme, Claude; Dombret, Hervé; Laurenti, Elisa; Macintyre, Elizabeth.
Afiliação
  • Bond J; Université de Paris, Institut Necker Enfants Malades (INEM), Institut national de la santé et de la recherche médicale (INSERM UMR1151), 75743, Paris, France.
  • Krzywon A; Laboratory of Onco-Hematology, Assistance Publique-Hôpitaux de Paris (AP-HP), Hôpital Necker-Enfants Malades, Paris, France.
  • Lhermitte L; Systems Biology Ireland, School of Medicine, University College Dublin, Dublin, Ireland.
  • Roumier C; National Children's Research Centre, Children's Health Ireland at Crumlin, Dublin, Ireland.
  • Roggy A; Department of Haematology, University of Cambridge, Cambridge, United Kingdom.
  • Belhocine M; Wellcome and MRC Cambridge Stem Cell Institute, University of Cambridge, Cambridge, United Kingdom.
  • Kheirallah AA; Silesian University of Technology, Department of Systems Biology and Engineering, Gliwice, Poland.
  • Villarese P; Maria Sklodowska-Curie National Research Institute of Oncology, Gliwice Branch, Gliwice, Poland.
  • Hypolite G; Université de Paris, Institut Necker Enfants Malades (INEM), Institut national de la santé et de la recherche médicale (INSERM UMR1151), 75743, Paris, France.
  • Garnache-Ottou F; Laboratory of Onco-Hematology, Assistance Publique-Hôpitaux de Paris (AP-HP), Hôpital Necker-Enfants Malades, Paris, France.
  • Castaigne S; Cancer Research Institute, INSERM Unité Mixte de Recherche (UMR)-S 1172, F-59000, Lille, France.
  • Boissel N; CHU Lille, Laboratory of Hematology, F-59000, Lille, France.
  • Asnafi V; Université de Paris, Institut Necker Enfants Malades (INEM), Institut national de la santé et de la recherche médicale (INSERM UMR1151), 75743, Paris, France.
  • Preudhomme C; Laboratory of Onco-Hematology, Assistance Publique-Hôpitaux de Paris (AP-HP), Hôpital Necker-Enfants Malades, Paris, France.
  • Dombret H; Univ. Bourgogne Franche-Comté, INSERM, EFS BFC, UMR1098, Interactions Hôte-Greffon-Tumeur/Ingénierie Cellulaire et Génique, F-25000, Besançon, France.
  • Laurenti E; Université de Paris, Institut Necker Enfants Malades (INEM), Institut national de la santé et de la recherche médicale (INSERM UMR1151), 75743, Paris, France.
  • Macintyre E; Laboratory of Onco-Hematology, Assistance Publique-Hôpitaux de Paris (AP-HP), Hôpital Necker-Enfants Malades, Paris, France.
Leukemia ; 35(3): 724-736, 2021 03.
Article em En | MEDLINE | ID: mdl-32655144
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Leucemia Aguda Bifenotípica / Leucemia Mieloide Aguda / Biomarcadores Tumorais / Diferenciação Celular / Leucemia-Linfoma Linfoblástico de Células Precursoras / Transcriptoma Tipo de estudo: Prognostic_studies Limite: Humans Idioma: En Ano de publicação: 2021 Tipo de documento: Article
Texto completo
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Leucemia Aguda Bifenotípica / Leucemia Mieloide Aguda / Biomarcadores Tumorais / Diferenciação Celular / Leucemia-Linfoma Linfoblástico de Células Precursoras / Transcriptoma Tipo de estudo: Prognostic_studies Limite: Humans Idioma: En Ano de publicação: 2021 Tipo de documento: Article