Clinical and Economic Evaluation after Adopting Contingent Cell-Free DNA Screening for Fetal Trisomies in South Spain.
Fetal Diagn Ther
; : 1-8, 2020 Jul 13.
Article
em En
| MEDLINE
| ID: mdl-32659771
ABSTRACT
INTRODUCTION:
Contingent cell-free (cf) DNA screening on the basis of the first-trimester combined test (FCT) results has emerged as a cost-effective strategy for screening of trisomy 21 (T21).OBJECTIVES:
To assess performance, patients' uptake, and cost of contingent cfDNA screening and to compare them with those of the established FCT.METHODS:
This is a prospective cohort study including all singleton pregnancies attending to their FCT for screening of T21 at 2 university hospitals in South Spain. When the FCT risk was ≥150, there were major fetal malformations, or the nuchal translucency was ≥3.5 mm, women were recommended invasive testing (IT); if the risk was between 150 and 1270, women were recommended cfDNA testing; and for risks bellow 1270, no further testing was recommended. Detection rate (DR), false-positive rate (FPR), patients' uptake, and associated costs were evaluated.RESULTS:
We analyzed 10,541 women, including 46 T21 cases. DR of our contingent strategy was 89.1% (41/46) at 1.4% (146/10,541) FPR. Uptake of cfDNA testing was 91.2% (340/373), and overall IT rate was 2.0%. The total cost of our strategy was 1,462,895.7, similar to 1,446,525.7 had cfDNA testing not been available.CONCLUSIONS:
Contingent cfDNA screening shows high DR, low IT rate, and high uptake at a similar cost than traditional screening.
Texto completo:
1
Base de dados:
MEDLINE
Tipo de estudo:
Diagnostic_studies
/
Health_economic_evaluation
/
Observational_studies
/
Risk_factors_studies
/
Screening_studies
Idioma:
En
Ano de publicação:
2020
Tipo de documento:
Article