Design and Synthesis of Near-Infrared Mechanically Interlocked Molecules for Specific Targeting of Mitochondria.
Org Lett
; 22(15): 5839-5843, 2020 08 07.
Article
em En
| MEDLINE
| ID: mdl-32663029
ABSTRACT
The entrapment of squaraine (SQ) within a molecular container to form rotaxane has been shown to improve the dye stability and the fluorescence proficiency inside the mitochondria. The macrocycle provides shelter and protects the near-infrared (NIR) SQ chromophore from nucleophilic attacks made by the exposed thiol of Cys-containing mitochondrial proteins and mitochondrial glutathione. Herein a microwave-assisted template-directed clipping reaction on low-loading 2-chlorotrityl chloride resin is used to develop an NIR unsymmetrical squaraine rotaxane in high quantum yield.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Fenóis
/
Ciclobutanos
/
Rotaxanos
/
Corantes Fluorescentes
/
Mitocôndrias
Idioma:
En
Ano de publicação:
2020
Tipo de documento:
Article