Articular damages in multi-generational female offspring due to prenatal caffeine exposure correlates with H3K9 deacetylation of TGFß signaling pathway.

Zhao, Zhe; Qin, Jun; Pei, Linguo; He, Zheng; Luo, Hanwen; Magdalou, Jacques; Chen, Liaobin; Wang, Hui

Zhao, Zhe; Qin, Jun; Pei, Linguo; He, Zheng; Luo, Hanwen; Magdalou, Jacques; Chen, Liaobin; Wang, Hui.

Afiliação

Zhao Z; Department of Orthopedic Surgery, Zhongnan Hospital of Wuhan University, Wuhan 430071, China; Department of Orthopedic Surgery, Xuyi County People's Hospital, Huai'an 211700, China.
Qin J; Department of Orthopedic Surgery, Zhongnan Hospital of Wuhan University, Wuhan 430071, China; Hubei Provincial Key Laboratory of Developmentally Originated Disease, Wuhan 430071, China.
Pei L; Department of Pharmacology, Wuhan University School of Basic Medical Sciences, Wuhan 430071, China.
He Z; Department of Pharmacology, Wuhan University School of Basic Medical Sciences, Wuhan 430071, China.
Luo H; Department of Orthopedic Surgery, Zhongnan Hospital of Wuhan University, Wuhan 430071, China.
Magdalou J; UMR 7561 CNRS-Université de Lorraine, Faculté de Médecine, Vandoeuvre-lès-Nancy, France.
Chen L; Department of Orthopedic Surgery, Zhongnan Hospital of Wuhan University, Wuhan 430071, China; Hubei Provincial Key Laboratory of Developmentally Originated Disease, Wuhan 430071, China. Electronic address: lbchen@whu.edu.cn.
Wang H; Department of Pharmacology, Wuhan University School of Basic Medical Sciences, Wuhan 430071, China; Hubei Provincial Key Laboratory of Developmentally Originated Disease, Wuhan 430071, China. Electronic address: wanghui19@whu.edu.cn.

Toxicology ; 442: 152533, 2020 09.

Article em En | MEDLINE | ID: mdl-32663519

Assuntos

Cafeína/toxicidade; Doenças das Cartilagens/induzido quimicamente; Cartilagem Articular/patologia; Estimulantes do Sistema Nervoso Central/toxicidade; Transdução de Sinais/efeitos dos fármacos; Fator de Crescimento Transformador beta/efeitos dos fármacos; Animais; Condrócitos/efeitos dos fármacos; Condrócitos/patologia; Condrogênese; Imunoprecipitação da Cromatina; Matriz Extracelular/patologia; Feminino; Glucocorticoides/farmacologia; Masculino; Gravidez; Efeitos Tardios da Exposição Pré-Natal; Ratos; Ratos Wistar

Palavras-chave

Damaged articular cartilage; H3K9 deacetylation; Multi-generational inheritance effect; Prenatal caffeine exposure; TGFß signaling pathway

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Cafeína / Transdução de Sinais / Cartilagem Articular / Doenças das Cartilagens / Fator de Crescimento Transformador beta / Estimulantes do Sistema Nervoso Central Limite: Animals / Pregnancy Idioma: En Ano de publicação: 2020 Tipo de documento: Article

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