Beyond What Your Retina Can See: Similarities of Retinoblastoma Function between Plants and Animals, from Developmental Processes to Epigenetic Regulation.
Int J Mol Sci
; 21(14)2020 Jul 12.
Article
em En
| MEDLINE
| ID: mdl-32664691
ABSTRACT
The Retinoblastoma protein (pRb) is a key cell cycle regulator conserved in a wide variety of organisms. Experimental analysis of pRb's functions in animals and plants has revealed that this protein participates in cell proliferation and differentiation processes. In addition, pRb in animals and its orthologs in plants (RBR), are part of highly conserved protein complexes which suggest the possibility that analogies exist not only between functions carried out by pRb orthologs themselves, but also in the structure and roles of the protein networks where these proteins are involved. Here, we present examples of pRb/RBR participation in cell cycle control, cell differentiation, and in the regulation of epigenetic changes and chromatin remodeling machinery, highlighting the similarities that exist between the composition of such networks in plants and animals.
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Texto completo:
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Base de dados:
MEDLINE
Assunto principal:
Proteínas de Plantas
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Proteína do Retinoblastoma
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Proteínas de Ciclo Celular
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Montagem e Desmontagem da Cromatina
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Epigênese Genética
Limite:
Animals
Idioma:
En
Ano de publicação:
2020
Tipo de documento:
Article