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Structure-based design, semi-synthesis and anti-inflammatory activity of tocotrienolic amides as 5-lipoxygenase inhibitors.
Dinh, Chau Phi; Ville, Alexia; Neukirch, Konstantin; Viault, Guillaume; Temml, Veronika; Koeberle, Andreas; Werz, Oliver; Schuster, Daniela; Stuppner, Hermann; Richomme, Pascal; Helesbeux, Jean-Jacques; Séraphin, Denis.
Afiliação
  • Dinh CP; SONAS, EA921, UNIV Angers, SFR QUASAV, Faculty of Health Sciences, Department of Pharmacy, 16 Bd Daviers, 49045, Angers Cedex 01, France.
  • Ville A; SONAS, EA921, UNIV Angers, SFR QUASAV, Faculty of Health Sciences, Department of Pharmacy, 16 Bd Daviers, 49045, Angers Cedex 01, France.
  • Neukirch K; Department of Pharmaceutical/Medicinal Chemistry, Institute of Pharmacy, Friedrich-Schiller-University Jena, Philosophenweg 14, 07743, Jena, Germany; Michael Popp Research Institute, University of Innsbruck, Mitterweg 24, 6020, Innsbruck, Austria.
  • Viault G; SONAS, EA921, UNIV Angers, SFR QUASAV, Faculty of Health Sciences, Department of Pharmacy, 16 Bd Daviers, 49045, Angers Cedex 01, France.
  • Temml V; Institute of Pharmacy/Pharmacognosy, University of Innsbruck, 80/82 Innrain, 6020, Innsbruck, Austria.
  • Koeberle A; Department of Pharmaceutical/Medicinal Chemistry, Institute of Pharmacy, Friedrich-Schiller-University Jena, Philosophenweg 14, 07743, Jena, Germany; Michael Popp Research Institute, University of Innsbruck, Mitterweg 24, 6020, Innsbruck, Austria.
  • Werz O; Department of Pharmaceutical/Medicinal Chemistry, Institute of Pharmacy, Friedrich-Schiller-University Jena, Philosophenweg 14, 07743, Jena, Germany.
  • Schuster D; Department of Pharmaceutical and Medicinal Chemistry, Paracelsus Medical University Salzburg, Strubergasse 21, 5020, Salzburg, Austria.
  • Stuppner H; Institute of Pharmacy/Pharmacognosy, University of Innsbruck, 80/82 Innrain, 6020, Innsbruck, Austria.
  • Richomme P; SONAS, EA921, UNIV Angers, SFR QUASAV, Faculty of Health Sciences, Department of Pharmacy, 16 Bd Daviers, 49045, Angers Cedex 01, France.
  • Helesbeux JJ; SONAS, EA921, UNIV Angers, SFR QUASAV, Faculty of Health Sciences, Department of Pharmacy, 16 Bd Daviers, 49045, Angers Cedex 01, France. Electronic address: jean-jacques.helesbeux@univ-angers.fr.
  • Séraphin D; SONAS, EA921, UNIV Angers, SFR QUASAV, Faculty of Health Sciences, Department of Pharmacy, 16 Bd Daviers, 49045, Angers Cedex 01, France.
Eur J Med Chem ; 202: 112518, 2020 Sep 15.
Article em En | MEDLINE | ID: mdl-32668380
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Vitamina E / Araquidonato 5-Lipoxigenase / Desenho de Fármacos / Anti-Inflamatórios não Esteroides / Inibidores de Lipoxigenase / Amidas Tipo de estudo: Prognostic_studies Limite: Humans Idioma: En Ano de publicação: 2020 Tipo de documento: Article
Texto completo
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Vitamina E / Araquidonato 5-Lipoxigenase / Desenho de Fármacos / Anti-Inflamatórios não Esteroides / Inibidores de Lipoxigenase / Amidas Tipo de estudo: Prognostic_studies Limite: Humans Idioma: En Ano de publicação: 2020 Tipo de documento: Article