[Comparison of the efficacy of domestic and imported caffeine citrate in the treatment of apnea in preterm infants: a prospective randomized double-blind controlled trial].
Zhongguo Dang Dai Er Ke Za Zhi
; 22(7): 684-689, 2020 Jul.
Article
em Zh
| MEDLINE
| ID: mdl-32669161
ABSTRACT
OBJECTIVE:
To compare the efficacy of domestic and imported caffeine citrate in the treatment of apnea in preterm infants.METHODS:
A total of 98 preterm infants with a gestational age of 28 - <34 weeks between April 2018 and December 2019 were enrolled. They were randomly administered with domestic (n=48) or imported caffeine citrate (n=50) within 6 hours after birth. The therapeutic effects, complications, adverse effects and clinical outcomes were compared between the two groups.RESULTS:
There were no significant differences in the incidence of apnea within 7 days after birth, daily frequency of apnea, the time of apnea disappearance, the failure rate of intubation-surfactant-extubation strategy, the time of non-invasive assisted ventilation, the duration of oxygen therapy, the duration of caffeine citrate therapy, the length of hospital stay, blood gas analysis results, liver and kidney function testing results between the two groups (P>0.05). There were no significant differences in the incidence of complications and the mortality rate between the two groups (P>0.05). There was no significant difference in the incidence of adverse effects between the two groups (P>0.05).CONCLUSIONS:
The efficacy and safety of domestic caffeine citrate in the treatment of apnea are similar to those of imported caffeine citrate in preterm infants.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Apneia
/
Cafeína
/
Citratos
/
Doenças do Prematuro
Tipo de estudo:
Clinical_trials
/
Observational_studies
/
Risk_factors_studies
Limite:
Humans
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Infant
/
Newborn
Idioma:
Zh
Ano de publicação:
2020
Tipo de documento:
Article