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Structure-based development of a subtype-selective orexin 1 receptor antagonist.
Hellmann, Jan; Drabek, Matthäus; Yin, Jie; Gunera, Jakub; Pröll, Theresa; Kraus, Frank; Langmead, Christopher J; Hübner, Harald; Weikert, Dorothee; Kolb, Peter; Rosenbaum, Daniel M; Gmeiner, Peter.
Afiliação
  • Hellmann J; Department of Chemistry and Pharmacy, Medicinal Chemistry, Friedrich-Alexander-Universität Erlangen-Nürnberg, 91058 Erlangen, Germany.
  • Drabek M; Department of Pharmaceutical Chemistry, Philipps-University Marburg, 35032 Marburg, Germany.
  • Yin J; Department of Biophysics, University of Texas Southwestern Medical Center, Dallas, TX 75390.
  • Gunera J; Department of Pharmaceutical Chemistry, Philipps-University Marburg, 35032 Marburg, Germany.
  • Pröll T; Department of Chemistry and Pharmacy, Medicinal Chemistry, Friedrich-Alexander-Universität Erlangen-Nürnberg, 91058 Erlangen, Germany.
  • Kraus F; Department of Chemistry and Pharmacy, Medicinal Chemistry, Friedrich-Alexander-Universität Erlangen-Nürnberg, 91058 Erlangen, Germany.
  • Langmead CJ; Drug Discovery Biology, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, VIC 3052, Australia.
  • Hübner H; Department of Chemistry and Pharmacy, Medicinal Chemistry, Friedrich-Alexander-Universität Erlangen-Nürnberg, 91058 Erlangen, Germany.
  • Weikert D; Department of Chemistry and Pharmacy, Medicinal Chemistry, Friedrich-Alexander-Universität Erlangen-Nürnberg, 91058 Erlangen, Germany.
  • Kolb P; Department of Pharmaceutical Chemistry, Philipps-University Marburg, 35032 Marburg, Germany; peter.kolb@uni-marburg.de dan.rosenbaum@utsouthwestern.edu peter.gmeiner@fau.de.
  • Rosenbaum DM; Department of Biophysics, University of Texas Southwestern Medical Center, Dallas, TX 75390; peter.kolb@uni-marburg.de dan.rosenbaum@utsouthwestern.edu peter.gmeiner@fau.de.
  • Gmeiner P; Department of Chemistry and Pharmacy, Medicinal Chemistry, Friedrich-Alexander-Universität Erlangen-Nürnberg, 91058 Erlangen, Germany; peter.kolb@uni-marburg.de dan.rosenbaum@utsouthwestern.edu peter.gmeiner@fau.de.
Proc Natl Acad Sci U S A ; 117(30): 18059-18067, 2020 07 28.
Article em En | MEDLINE | ID: mdl-32669442
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Simulação de Dinâmica Molecular / Simulação de Acoplamento Molecular / Receptores de Orexina / Antagonistas dos Receptores de Orexina Tipo de estudo: Prognostic_studies Idioma: En Ano de publicação: 2020 Tipo de documento: Article
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Simulação de Dinâmica Molecular / Simulação de Acoplamento Molecular / Receptores de Orexina / Antagonistas dos Receptores de Orexina Tipo de estudo: Prognostic_studies Idioma: En Ano de publicação: 2020 Tipo de documento: Article