Radix Sophorae Flavescentis induces apoptosis through by Caspase, MAPK Activation and ROS Signaling Pathways in 5637 Human Bladder Cancer Cells.
Int J Med Sci
; 17(11): 1474-1481, 2020.
Article
em En
| MEDLINE
| ID: mdl-32669949
ABSTRACT
The anti-cancer mechanisms of Radix Sophorae Flavescentis were investigated in 5637 bladder cancer cells. Radix Sophorae Flavescentis extract (RSF) (50400 µg/ml) inhibited the proliferation of 5637 cells and increased subG1 phase ratios. RSFinduced cell death was associated with the down-regulation of Bcell lymphoma 2 (Bcl2) and the up-regulation of Bcl2 Xassociated protein (Bax). RSF also activated caspase3 and -9 and regulated the activations of mitogen-activated protein kinases (MAPKs). In addition, RSF increased intracellular reactive oxygen species (ROS) levels and depolarized the mitochondrial membrane potential. These findings suggest RSF induces apoptosis in 5637 bladder cancer cells and that it has potential use as a novel anti-cancer drug for bladder cancer.
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Texto completo:
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Base de dados:
MEDLINE
Assunto principal:
Neoplasias da Bexiga Urinária
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Medicamentos de Ervas Chinesas
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Espécies Reativas de Oxigênio
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Caspases
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Proteínas Quinases Ativadas por Mitógeno
Limite:
Humans
Idioma:
En
Ano de publicação:
2020
Tipo de documento:
Article