Low medication adherence is associated with decline in health-related quality of life: results of a longitudinal analysis among older women and men with hypertension.
J Hypertens
; 39(1): 153-161, 2021 01.
Article
em En
| MEDLINE
| ID: mdl-32675745
ABSTRACT
OBJECTIVE:
The aim of this study was to determine the association of low antihypertensive medication adherence with decline in health-related quality of life (HRQOL) over 1 year.METHODS:
We used data from older men and women with hypertension (nâ=â1525) enrolled in the Cohort Study of Medication Adherence among Older Adults. Adherence was measured using the validated self-report four-item Krousel-Wood Medication Adherence Scale (K-Wood-MAS-4) (low adherenceâ=âscore ≥1) and prescription refill-based proportion of days covered (PDC) (low adherenceâ=âPDCâ<â0.80). We defined decline in HRQOL as a decrease in Mental Component Summary (MCS) or Physical Component Summary (PCS) score (from the RAND 36-Item Health Survey 1.0 administered at two time points - at the time of adherence assessment and 1 year later) equivalent to the minimal important difference (MID) for each respective summary score, calculated as the average of MID estimates derived from distribution and anchor-based approaches.RESULTS:
The prevalence of low adherence was 38.6% using the K-Wood-MAS-4 and 23.9% using PDC. On the basis of mean MID estimates of 4.40 for MCS and 5.16 for PCS, 21.8 and 25.2% of participants experienced a decline in MCS and PCS, respectively, over 1 year. Low adherence was associated with a decline in MCS for K-Wood-MAS-4 [prevalence ratioâ=â1.32, 95% confidence interval (95% CI) 1.08-1.62, Pâ=â0.008], but not PDC (prevalence ratio â=â1.17, 95% CI 0.94-1.47, Pâ=â0.168). Low adherence was not associated with decline in PCS (K-Wood-MAS-4 prevalence ratio â=â0.95, 95% CI 0.79-1.16; PDC prevalence ratio â=â1.10, 95% CI 0.90-1.35).CONCLUSION:
Low self-report medication adherence is associated with decline in mental HRQOL over 1 year in older adults with hypertension.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Qualidade de Vida
/
Hipertensão
Tipo de estudo:
Etiology_studies
/
Incidence_studies
/
Observational_studies
/
Risk_factors_studies
Limite:
Aged
/
Female
/
Humans
/
Male
Idioma:
En
Ano de publicação:
2021
Tipo de documento:
Article