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Detection of Mycobacterium Tuberculosis DNA in Buccal Swab Samples from Children in Lima, Peru.
Flores, Juan A; Calderón, Roger; Mesman, Annelies W; Soto, Martin; Coit, Julia; Aliaga, Juan; Mendoza, Milagros; Leon, Segundo R; Konda, Kelika; Mestanza, Francisco M; Mendoza, Carlos J; Lecca, Leonid; Murray, Megan B; Holmberg, Rebecca C; Pollock, Nira R; Franke, Molly F.
Afiliação
  • Flores JA; From the Escuela de Tecnología Médica, Universidad Privada San Juan Bautista, Lima, Peru.
  • Calderón R; Facultad de Salud Pública, Universidad Peruana Cayetano Heredia, Lima, Peru.
  • Mesman AW; Socios En Salud Sucursal Peru, Lima, Peru.
  • Soto M; Faculdade de Medicina, Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brazil.
  • Coit J; Department of Global Health and Social Medicine, Harvard Medical School, Boston, Massachusetts.
  • Aliaga J; Socios En Salud Sucursal Peru, Lima, Peru.
  • Mendoza M; Department of Global Health and Social Medicine, Harvard Medical School, Boston, Massachusetts.
  • Leon SR; Faculdade de Medicina, Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brazil.
  • Konda K; Socios En Salud Sucursal Peru, Lima, Peru.
  • Mestanza FM; From the Escuela de Tecnología Médica, Universidad Privada San Juan Bautista, Lima, Peru.
  • Mendoza CJ; Centro de Investigación Interdisciplinaria en Sexualidad, Sida y Sociedad, Universidad Peruana Cayetano Heredia, Lima, Peru.
  • Lecca L; Hospital Nacional Docente Madre Niño San Bartolomé, Ministerio de Salud del Peru, Lima, Peru.
  • Murray MB; Hospital Nacional Hipólito Unanue, Ministerio de Salud del Peru, Lima, Peru.
  • Holmberg RC; Socios En Salud Sucursal Peru, Lima, Peru.
  • Pollock NR; Department of Global Health and Social Medicine, Harvard Medical School, Boston, Massachusetts.
  • Franke MF; Akonni Biosystems Inc, Frederick, Maryland.
Pediatr Infect Dis J ; 39(11): e376-e380, 2020 11.
Article em En | MEDLINE | ID: mdl-32675773
We examined Mycobacterium tuberculosis DNA detection from buccal swab samples collected from children in Lima, Peru. DNA was extracted and amplified via real-time polymerase chain reaction. Sensitivity was 21% (95% confidence interval [CI]: 7%-42%) in 24 culture-confirmed tuberculosis cases and 4.6% (95% CI: 1%-13%) in 65 clinically diagnosed unconfirmed cases. Sensitivity was highest for smear-positive tuberculosis. Specificity was 99% in the 199 controls (95% CI: 96%-100%).
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: DNA Bacteriano / Mucosa Bucal / Mycobacterium tuberculosis Tipo de estudo: Diagnostic_studies Limite: Adolescent / Child / Female / Humans / Male País como assunto: America do sul / Peru Idioma: En Ano de publicação: 2020 Tipo de documento: Article
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: DNA Bacteriano / Mucosa Bucal / Mycobacterium tuberculosis Tipo de estudo: Diagnostic_studies Limite: Adolescent / Child / Female / Humans / Male País como assunto: America do sul / Peru Idioma: En Ano de publicação: 2020 Tipo de documento: Article