Association of slow acetylator genotype of N-acetyltransferase 2 with Parkinson's disease in south Indian population.
Neurosci Lett
; 735: 135260, 2020 09 14.
Article
em En
| MEDLINE
| ID: mdl-32682841
ABSTRACT
AIM:
Parkinson's Disease (PD) is a neurodegenerative disorder with predisposing genetic and environmental factors. The present study was undertaken to elucidate the possible association of NAT2 gene polymorphism in PD patients from south India.METHODS:
Using previously validated PCR-RFLP assays, we genotyped 105 PD subjects and 101 healthy controls for N-acetyl transferase (NAT2) gene polymorphism.RESULTS:
We observed a significantly elevated frequencies of NAT2 *5/6 (ORâ¯=â¯4.21; pâ¯<â¯0.029) and *5/7 (ORâ¯=â¯2.73; pâ¯<â¯0.025) genotypes and NAT2*5 (ORâ¯=â¯1.83; pâ¯<â¯0.039) allele among PD cases showing susceptible associations. The age at onset analysis revealed a significant association of NAT2 *4/6 (ORâ¯=â¯4.62; pâ¯<â¯0.05) genotype with early onset PD (EOPD). A positive association with early onset disease was observed for *5/7 (ORâ¯=â¯3.88; pâ¯<â¯0.075) genotype, however without statistical significance. Whereas, in late onset PD (LOPD) cases, significant susceptible association was observed for NAT2 *5/7 (ORâ¯=â¯5.27; pâ¯<â¯0.029) genotype. We observed a highly significant protective association of NAT2 *4/6 (ORâ¯=â¯0.27; pâ¯<â¯0.012) genotype and NAT2 *4 (ORâ¯=â¯0.52; pâ¯<â¯0.027) allele with LOPD. The acetylator status phenotype analysis have revealed a higher risk for, 'NAT2 slow acetylator' in both overall PD (ORâ¯=â¯2.39; pâ¯<â¯0.002) and LOPD (ORâ¯=â¯2.88; pâ¯<â¯0.007). However, 'NAT2 intermediate acetylator' with a lower risk in both overall PD (ORâ¯=â¯0.47; pâ¯<â¯0.011) and LOPD (ORâ¯=â¯0.36; pâ¯<â¯0.007) cases revealed protective associations.CONCLUSIONS:
Thus, our results revealed the possible susceptible association of NAT2 slow acetylator in PD pathogenesis in south Indian population.Palavras-chave
Texto completo:
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Base de dados:
MEDLINE
Assunto principal:
Doença de Parkinson
/
Arilamina N-Acetiltransferase
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Predisposição Genética para Doença
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Polimorfismo de Nucleotídeo Único
/
Estudos de Associação Genética
/
Genótipo
Tipo de estudo:
Diagnostic_studies
/
Prognostic_studies
/
Risk_factors_studies
Limite:
Aged
/
Female
/
Humans
/
Male
/
Middle aged
País como assunto:
Asia
Idioma:
En
Ano de publicação:
2020
Tipo de documento:
Article