CTCF promotes colorectal cancer cell proliferation and chemotherapy resistance to 5-FU via the P53-Hedgehog axis.

Lai, Qiuhua; Li, Qingyuan; He, Chengcheng; Fang, Yuxin; Lin, Simin; Cai, Jianqun; Ding, Jian; Zhong, Qian; Zhang, Yue; Wu, Changjie; Wang, Xinke; He, Juan; Liu, Yongfeng; Yan, Qun; Li, Aimin; Liu, Side

Lai, Qiuhua; Li, Qingyuan; He, Chengcheng; Fang, Yuxin; Lin, Simin; Cai, Jianqun; Ding, Jian; Zhong, Qian; Zhang, Yue; Wu, Changjie; Wang, Xinke; He, Juan; Liu, Yongfeng; Yan, Qun; Li, Aimin; Liu, Side.

Afiliação

Lai Q; Guangdong Provincial Key Laboratory of Gastroenterology, Department of Gastroenterology, Nanfang Hospital, Southern Medical University, Guangzhou, Guangdong, China.
Li Q; Guangdong Provincial Key Laboratory of Gastroenterology, Department of Gastroenterology, Nanfang Hospital, Southern Medical University, Guangzhou, Guangdong, China.
He C; Guangdong Provincial Key Laboratory of Gastroenterology, Department of Gastroenterology, Nanfang Hospital, Southern Medical University, Guangzhou, Guangdong, China.
Fang Y; Guangdong Provincial Key Laboratory of Gastroenterology, Department of Gastroenterology, Nanfang Hospital, Southern Medical University, Guangzhou, Guangdong, China.
Lin S; Guangdong Provincial Key Laboratory of Gastroenterology, Department of Gastroenterology, Nanfang Hospital, Southern Medical University, Guangzhou, Guangdong, China.
Cai J; Guangdong Provincial Key Laboratory of Gastroenterology, Department of Gastroenterology, Nanfang Hospital, Southern Medical University, Guangzhou, Guangdong, China.
Ding J; Guangdong Provincial Key Laboratory of Gastroenterology, Department of Gastroenterology, Nanfang Hospital, Southern Medical University, Guangzhou, Guangdong, China.
Zhong Q; Guangdong Provincial Key Laboratory of Gastroenterology, Department of Gastroenterology, Nanfang Hospital, Southern Medical University, Guangzhou, Guangdong, China.
Zhang Y; Guangdong Provincial Key Laboratory of Gastroenterology, Department of Gastroenterology, Nanfang Hospital, Southern Medical University, Guangzhou, Guangdong, China.
Wu C; Guangdong Provincial Key Laboratory of Gastroenterology, Department of Gastroenterology, Nanfang Hospital, Southern Medical University, Guangzhou, Guangdong, China.
Wang X; Guangdong Provincial Key Laboratory of Gastroenterology, Department of Gastroenterology, Nanfang Hospital, Southern Medical University, Guangzhou, Guangdong, China.
He J; Guangdong Provincial Key Laboratory of Gastroenterology, Department of Gastroenterology, Nanfang Hospital, Southern Medical University, Guangzhou, Guangdong, China.
Liu Y; Guangdong Provincial Key Laboratory of Gastroenterology, Department of Gastroenterology, Nanfang Hospital, Southern Medical University, Guangzhou, Guangdong, China.
Yan Q; Guangdong Provincial Key Laboratory of Gastroenterology, Department of Gastroenterology, Nanfang Hospital, Southern Medical University, Guangzhou, Guangdong, China.
Li A; Guangdong Provincial Key Laboratory of Gastroenterology, Department of Gastroenterology, Nanfang Hospital, Southern Medical University, Guangzhou, Guangdong, China.
Liu S; Guangdong Provincial Key Laboratory of Gastroenterology, Department of Gastroenterology, Nanfang Hospital, Southern Medical University, Guangzhou, Guangdong, China.

Aging (Albany NY) ; 12(16): 16270-16293, 2020 07 20.

Article em En | MEDLINE | ID: mdl-32688344

Assuntos

Antimetabólitos Antineoplásicos/farmacologia; Fator de Ligação a CCCTC/metabolismo; Proliferação de Células/efeitos dos fármacos; Neoplasias Colorretais/tratamento farmacológico; Resistencia a Medicamentos Antineoplásicos; Fluoruracila/farmacologia; Proteínas Hedgehog/metabolismo; Proteína Supressora de Tumor p53/metabolismo; Animais; Apoptose/efeitos dos fármacos; Fator de Ligação a CCCTC/genética; Neoplasias Colorretais/genética; Neoplasias Colorretais/metabolismo; Neoplasias Colorretais/patologia; Resistencia a Medicamentos Antineoplásicos/genética; Regulação Neoplásica da Expressão Gênica; Células HCT116; Células HT29; Humanos; Camundongos Endogâmicos BALB C; Camundongos Nus; Transdução de Sinais; Carga Tumoral/efeitos dos fármacos; Proteína Supressora de Tumor p53/genética; Ensaios Antitumorais Modelo de Xenoenxerto

Palavras-chave

CTCF; Hedgehog; P53; chemotherapy resistance; colorectal cancer

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Neoplasias Colorretais / Proteína Supressora de Tumor p53 / Resistencia a Medicamentos Antineoplásicos / Proliferação de Células / Proteínas Hedgehog / Fluoruracila / Fator de Ligação a CCCTC / Antimetabólitos Antineoplásicos Tipo de estudo: Prognostic_studies Limite: Animals / Humans Idioma: En Ano de publicação: 2020 Tipo de documento: Article

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