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Discovery of a Highly Selective Sigma-2 Receptor Ligand, 1-(4-(6,7-Dimethoxy-3,4-dihydroisoquinolin-2(1H)-yl)butyl)-3-methyl-1H-benzo[d]imidazol-2(3H)-one (CM398), with Drug-Like Properties and Antinociceptive Effects In Vivo.
Intagliata, Sebastiano; Sharma, Abhisheak; King, Tamara I; Mesangeau, Christophe; Seminerio, Michael; Chin, Frederick T; Wilson, Lisa L; Matsumoto, Rae R; McLaughlin, Jay P; Avery, Bonnie A; McCurdy, Christopher R.
Afiliação
  • Intagliata S; Department of Medicinal Chemistry, College of Pharmacy, University of Florida, Gainesville, Florida, 32610, USA.
  • Sharma A; Department of Pharmaceutics, College of Pharmacy, University of Florida, Gainesville, Florida, 32610, USA.
  • King TI; Department of Pharmaceutics, College of Pharmacy, University of Florida, Gainesville, Florida, 32610, USA.
  • Mesangeau C; Department of BioMolecular Sciences, School of Pharmacy, The University of Mississippi, University, Mississippi, 38677, USA.
  • Seminerio M; Department of Basic Pharmaceutical Sciences, West Virginia University, Morgantown, West Virginia, 26506, USA.
  • Chin FT; Department of Radiology, Stanford University School of Medicine, Stanford, California, 94305, USA.
  • Wilson LL; Department of Pharmacodynamics, College of Pharmacy, University of Florida, Gainesville, Florida, 32610, USA.
  • Matsumoto RR; Department of Basic Pharmaceutical Sciences, West Virginia University, Morgantown, West Virginia, 26506, USA.
  • McLaughlin JP; Dean's Office, Touro University California College of Pharmacy, Vallejo, CA, 94592, USA.
  • Avery BA; Department of Pharmacodynamics, College of Pharmacy, University of Florida, Gainesville, Florida, 32610, USA.
  • McCurdy CR; Department of Pharmaceutics, College of Pharmacy, University of Florida, Gainesville, Florida, 32610, USA.
AAPS J ; 22(5): 94, 2020 07 20.
Article em En | MEDLINE | ID: mdl-32691179
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Receptores sigma / Analgésicos Limite: Animals Idioma: En Ano de publicação: 2020 Tipo de documento: Article
Texto completo
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XML
PubMed Links
Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Receptores sigma / Analgésicos Limite: Animals Idioma: En Ano de publicação: 2020 Tipo de documento: Article