Cytotoxic diterpenoids from the leaves and stem bark of Croton haumanianus (Euphorbiaceae).
Phytochemistry
; 178: 112455, 2020 Oct.
Article
em En
| MEDLINE
| ID: mdl-32692659
ABSTRACT
The leaf extract of Croton haumanianus J. Léonard (Euphorbiaceae) yielded twenty-six compounds, including eight previously reported ent-kauranes and an ent-labdane and eight undescribed ent-kauranes, ent-16R-kauran-17-al, ent-3ß-hydroxy-16R-kauran-17-al, ent-16S,17-epoxykauran-19-ol, ent-16S,17-epoxykauran-3ß-ol, ent-17-palmityloxykaurane-3ß,16ß-diol, ent-17-palmityloxykauran-16ß-ol, ent-3α,18-cyclokaurane-16ß,17-diol and 19-nor-16α,17-dihydroxy-ent-kaur-4(18)-ene and three undescribed ent-clerodanes, dimethyl ent-15,16-epoxy-6ß-hydroxy-1,3,13(16),14-clerodatetraen-20,12S-olide-18,19-dioate (saniolide A), dimethyl ent-15,16-epoxy-6ß-hydroxy-1,3,13(16),14-clerodatetraen-20,12R-olide-18,19-dioate (12-epi-saniolide A), methyl ent-15,16-epoxy-1,3,13(16),14-clerodatetraen-18,6R20,12S-diolide-19-oate (saniolide B). The stem bark extract yielded the ent-clerodane crotocorylifuran, and five undescribed ent-isopimaranes, ent-isopimara-8(14),15-dien-18-al, ent-18-hydroxyisopimara-8(14),15-dien-7-one, ent-isopimara-7,15-dien-18-oic acid, ent-isopimara-7,15-dien-18-ol and ent-isopimara-8,15-dien-7-oxo-18-oic acid. Three compounds, ent-kaurane-3ß,16ß,17-triol, ent-17-palmityloxykaurane-3ß,16ß-diol and ent-17-palmityloxykauran-16ß-ol, showed selective activity against three of the NCI 60 cancer cell lines, the colon (HCT-116), the melanoma (M14) and the renal (786-0) cancer cell lines at a concentration of 10-5 M.
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Base de dados:
MEDLINE
Assunto principal:
Euphorbiaceae
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Croton
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Diterpenos do Tipo Caurano
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Diterpenos
Idioma:
En
Ano de publicação:
2020
Tipo de documento:
Article