It Takes Two to Tango: DPRs in ALS and SCA36.

Maharjan, Niran; Saxena, Smita

Maharjan, Niran; Saxena, Smita.

Afiliação

Maharjan N; Department of Neurology, Inselspital University Hospital, 3010 Bern, Switzerland; Department for BioMedical Research, University of Bern, 3008 Bern, Switzerland.
Saxena S; Department of Neurology, Inselspital University Hospital, 3010 Bern, Switzerland; Department for BioMedical Research, University of Bern, 3008 Bern, Switzerland. Electronic address: smita.saxena@dbmr.unibe.ch.

Neuron ; 107(2): 202-204, 2020 07 22.

Article em En | MEDLINE | ID: mdl-32702342

ABSTRACT

ABSTRACT

Dipeptide repeat proteins (DPRs) occur via repeat-associated non-AUG (RAN) translation. In this issue of Neuron, McEachin et al. (2020) show that the aggregation-prone poly(GA)-rich chimeric DPRs determine divergent poly(GP) mediated pathology between C9ALS/FTD and SCA36.

Assuntos

Esclerose Lateral Amiotrófica; Demência Frontotemporal; Proteína C9orf72; Dipeptídeos; Humanos

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Demência Frontotemporal / Esclerose Lateral Amiotrófica Limite: Humans Idioma: En Ano de publicação: 2020 Tipo de documento: Article

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