Prostaglandin D2 metabolite is not a useful clinical indicator for assessing atopic dermatitis.
Clin Exp Dermatol
; 46(1): 130-134, 2021 Jan.
Article
em En
| MEDLINE
| ID: mdl-32705704
ABSTRACT
Prostaglandin D2 (PGD2 ) plays an important role in atopic dermatitis (AD), and 11,15-dioxo-9α-hydroxy-2,3,4,5-tetranorprostan-1,20-dioicacid (PGDM) is a major metabolite of PGD2 . We investigated the relationship between urinary PGDM levels and severity of paediatric AD. In total, 31 patients with AD and 21 healthy controls (HCs) without AD were recruited, and urinary PGDM levels were measured. Of the 31 patients with AD, 14 were reassessed for urinary PGDM after topical steroid therapy. There was no difference in urinary PGDM levels between patients with AD and HCs. Although there was a significant positive correlation between the SCORing Atopic Dermatitis (SCORAD) index and the serum level of thymus and activation-regulated chemokine (TARC), the urinary PGDM levels did not correlate with either SCORAD or serum TARC. Moreover, both SCORAD and serum TARC were significantly improved by topical steroid therapy; however, urinary PGDM levels were not changed. In conclusion, the level of urinary PGD2 metabolites in children with AD is substantially the same as that in HCs even if the disease is severe.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Prostaglandina D2
/
Dermatite Atópica
Tipo de estudo:
Observational_studies
Limite:
Child
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Child, preschool
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Female
/
Humans
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Male
Idioma:
En
Ano de publicação:
2021
Tipo de documento:
Article