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Cell Growth Inhibition of Saponin XII from Dipsacus japonicus Miq. on Acute Myeloid Leukemia Cells.
Cham, Ba Thi; Linh, Nguyen Thi Thuy; Thao, Do Thi; Anh, Nguyen Thi Hoang; Tam, Nguyen Thanh; Anh, Bui Kim; Muscari, Isabella; Adorisio, Sabrina; Sung, Tran Van; Thuy, Trinh Thi; Delfino, Domenico V.
Afiliação
  • Cham BT; Department of Chemistry, Graduate University of Science and Technology, Vietnam Academy of Science and Technology (VAST), 18 Hoang Quoc Viet, Nghia Do, Cau Giay, 100000 Hanoi, Vietnam.
  • Linh NTT; Department of Natural Products Research, Institute of Chemistry, VAST, 18 Hoang Quoc Viet, Nghia Do, Cau Giay, 100000 Hanoi, Vietnam.
  • Thao DT; Department of Chemistry, Graduate University of Science and Technology, Vietnam Academy of Science and Technology (VAST), 18 Hoang Quoc Viet, Nghia Do, Cau Giay, 100000 Hanoi, Vietnam.
  • Anh NTH; Department of Natural Products Research, Institute of Chemistry, VAST, 18 Hoang Quoc Viet, Nghia Do, Cau Giay, 100000 Hanoi, Vietnam.
  • Tam NT; Department of Chemistry, Graduate University of Science and Technology, Vietnam Academy of Science and Technology (VAST), 18 Hoang Quoc Viet, Nghia Do, Cau Giay, 100000 Hanoi, Vietnam.
  • Anh BK; Institute of Biotechnology, VAST, 18 Hoang Quoc Viet, Nghia Do, Cau Giay, 100000 Hanoi, Vietnam.
  • Muscari I; Department of Chemistry, Graduate University of Science and Technology, Vietnam Academy of Science and Technology (VAST), 18 Hoang Quoc Viet, Nghia Do, Cau Giay, 100000 Hanoi, Vietnam.
  • Adorisio S; Department of Natural Products Research, Institute of Chemistry, VAST, 18 Hoang Quoc Viet, Nghia Do, Cau Giay, 100000 Hanoi, Vietnam.
  • Sung TV; Department of Chemistry, Graduate University of Science and Technology, Vietnam Academy of Science and Technology (VAST), 18 Hoang Quoc Viet, Nghia Do, Cau Giay, 100000 Hanoi, Vietnam.
  • Thuy TT; Department of Natural Products Research, Institute of Chemistry, VAST, 18 Hoang Quoc Viet, Nghia Do, Cau Giay, 100000 Hanoi, Vietnam.
  • Delfino DV; Department of Natural Products Research, Institute of Chemistry, VAST, 18 Hoang Quoc Viet, Nghia Do, Cau Giay, 100000 Hanoi, Vietnam.
Molecules ; 25(15)2020 Jul 22.
Article em En | MEDLINE | ID: mdl-32707961
ABSTRACT
In previous studies, we isolated the known compound saponin XII from the roots of Dipsacus japonicus Miq. Here, we show that this compound reduced the number of acute myeloid leukemia OCI-AML3 cells as evaluated by a hemocytometer. Flow cytometry analyses demonstrated that the reported activity was associated with a significant increase of apoptosis and of cells in the G0/G1 phase of the cell cycle, with a decrease of cells in the S and G2/M phases. Thus, the inhibition of cell growth in OCI-AML3 cells was due to antiproliferative and pro-apoptotic effects. Interestingly, the bioactivity of saponin XII exerted its effect at a concentration as low as 1 µg/mL.
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Saponinas / Extratos Vegetais / Leucemia Mieloide Aguda / Dipsacaceae / Inibidores do Crescimento / Antineoplásicos Limite: Humans Idioma: En Ano de publicação: 2020 Tipo de documento: Article
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Saponinas / Extratos Vegetais / Leucemia Mieloide Aguda / Dipsacaceae / Inibidores do Crescimento / Antineoplásicos Limite: Humans Idioma: En Ano de publicação: 2020 Tipo de documento: Article