CTRP9 induces macrophages polarization into M1 phenotype through activating JNK pathway and enhances VSMCs apoptosis in macrophages and VSMCs co-culture system.

Chen, Ji-Ying; Song, Cheng-Xiang; Lei, Sheng-Yun; Li, Jun; Zuo, An-Ju; Xu, Dan; Guo, Yuan

Chen, Ji-Ying; Song, Cheng-Xiang; Lei, Sheng-Yun; Li, Jun; Zuo, An-Ju; Xu, Dan; Guo, Yuan.

Afiliação

Chen JY; Department of General Practice, Qilu Hospital of Shandong University, Jinan, China; The Key Laboratory of Cardiovascular Remodeling and Function Research, Chinese Ministry of Education, Chinese National Health Commission and Chinese Academy of Medical Sciences, The State and Shandong Province Joint
Song CX; The Key Laboratory of Cardiovascular Remodeling and Function Research, Chinese Ministry of Education, Chinese National Health Commission and Chinese Academy of Medical Sciences, The State and Shandong Province Joint Key Laboratory of Translational Cardiovascular Medicine, Qilu Hospital of Shandong U
Lei SY; Department of General Practice, Qilu Hospital of Shandong University, Jinan, China; The Key Laboratory of Cardiovascular Remodeling and Function Research, Chinese Ministry of Education, Chinese National Health Commission and Chinese Academy of Medical Sciences, The State and Shandong Province Joint
Li J; Department of General Practice, Qilu Hospital of Shandong University, Jinan, China; The Key Laboratory of Cardiovascular Remodeling and Function Research, Chinese Ministry of Education, Chinese National Health Commission and Chinese Academy of Medical Sciences, The State and Shandong Province Joint
Zuo AJ; Department of General Practice, Qilu Hospital of Shandong University, Jinan, China; The Key Laboratory of Cardiovascular Remodeling and Function Research, Chinese Ministry of Education, Chinese National Health Commission and Chinese Academy of Medical Sciences, The State and Shandong Province Joint
Xu D; Department of General Practice, Qilu Hospital of Shandong University, Jinan, China; The Key Laboratory of Cardiovascular Remodeling and Function Research, Chinese Ministry of Education, Chinese National Health Commission and Chinese Academy of Medical Sciences, The State and Shandong Province Joint
Guo Y; Department of General Practice, Qilu Hospital of Shandong University, Jinan, China. Electronic address: Guoyuanarticle2000@163.com.

Exp Cell Res ; 395(1): 112194, 2020 10 01.

Article em En | MEDLINE | ID: mdl-32712018

Assuntos

Adiponectina/farmacologia; Apoptose/efeitos dos fármacos; Glicoproteínas/farmacologia; Ativação de Macrófagos/efeitos dos fármacos; Macrófagos/efeitos dos fármacos; Músculo Liso Vascular/efeitos dos fármacos; Adiponectina/metabolismo; Animais; Técnicas de Cocultura; Glicoproteínas/metabolismo; Lipopolissacarídeos/farmacologia; Macrófagos/metabolismo; Camundongos; Proteínas Quinases Ativadas por Mitógeno/metabolismo; Músculo Liso Vascular/metabolismo; Fosforilação/efeitos dos fármacos; Transdução de Sinais/efeitos dos fármacos; Regulação para Cima/efeitos dos fármacos

Palavras-chave

CTRP9; Co-culture system; JNK; Macrophages polarization; VSMCs apoptosis

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Glicoproteínas / Apoptose / Adiponectina / Ativação de Macrófagos / Macrófagos / Músculo Liso Vascular Tipo de estudo: Prognostic_studies Limite: Animals Idioma: En Ano de publicação: 2020 Tipo de documento: Article

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