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Characterisation of the transcriptome and proteome of SARS-CoV-2 reveals a cell passage induced in-frame deletion of the furin-like cleavage site from the spike glycoprotein.
Davidson, Andrew D; Williamson, Maia Kavanagh; Lewis, Sebastian; Shoemark, Deborah; Carroll, Miles W; Heesom, Kate J; Zambon, Maria; Ellis, Joanna; Lewis, Philip A; Hiscox, Julian A; Matthews, David A.
Afiliação
  • Davidson AD; School of Cellular and Molecular Medicine, Faculty of Life Sciences, University Walk, University of Bristol, Bristol, BS8 1TD, UK. andrew.davidson@bristol.ac.uk.
  • Williamson MK; School of Cellular and Molecular Medicine, Faculty of Life Sciences, University Walk, University of Bristol, Bristol, BS8 1TD, UK.
  • Lewis S; School of Cellular and Molecular Medicine, Faculty of Life Sciences, University Walk, University of Bristol, Bristol, BS8 1TD, UK.
  • Shoemark D; School of Biochemistry, Faculty of Life Sciences, University Walk, University of Bristol, Bristol, BS8 1TD, UK.
  • Carroll MW; Research and Development Institute, National Infection Service, Public Health, England, Porton Down, Wiltshire, UK.
  • Heesom KJ; National Institute Health Research, Health Protection Research Unit in Emerging and Zoonotic Infections, Liverpool, UK.
  • Zambon M; Proteomics Facility Faculty of Life Sciences, University Walk, University of Bristol, Bristol, BS8 1TD, UK.
  • Ellis J; Virus Reference Department, Public Health England (Colindale), London, UK.
  • Lewis PA; Virus Reference Department, Public Health England (Colindale), London, UK.
  • Hiscox JA; School of Cellular and Molecular Medicine, Faculty of Life Sciences, University Walk, University of Bristol, Bristol, BS8 1TD, UK.
  • Matthews DA; National Institute Health Research, Health Protection Research Unit in Emerging and Zoonotic Infections, Liverpool, UK.
Genome Med ; 12(1): 68, 2020 07 28.
Article em En | MEDLINE | ID: mdl-32723359
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Deleção de Sequência / Perfilação da Expressão Gênica / Proteômica / Glicoproteína da Espícula de Coronavírus / Betacoronavirus Tipo de estudo: Prognostic_studies Limite: Animals Idioma: En Ano de publicação: 2020 Tipo de documento: Article
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Deleção de Sequência / Perfilação da Expressão Gênica / Proteômica / Glicoproteína da Espícula de Coronavírus / Betacoronavirus Tipo de estudo: Prognostic_studies Limite: Animals Idioma: En Ano de publicação: 2020 Tipo de documento: Article